Dscaml1 DS cell adhesion molecule like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dscaml1provided by MGI
Official Full Name: DS cell adhesion molecule like 1provided by MGI
Primary source: MGI:MGI:2150309
See related: Ensembl:ENSMUSG00000032087 AllianceGenome:MGI:2150309
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1132; 4921507G06Rik; 4930435C18Rik
Summary: Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Involved in dendrite self-avoidance and negative regulation of cell adhesion. Predicted to be located in cell surface. Predicted to be active in axon and plasma membrane. Is expressed in several structures, including genitourinary system; liver; nervous system; nose; and spleen. Orthologous to human DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 8.0), CNS E18 (RPKM 7.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (45338735..45665011)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (45427433..45753713)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The rod synapse in aging wildtype and Dscaml1 mutant mice.
Title: The rod synapse in aging wildtype and Dscaml1 mutant mice.
Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
Title: Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
Together, these results demonstrate that different cell types have different dependencies on the PDZ-interacting C-termini of DSCAM and DSCAML1 for function, indicating multiple intracellular molecular mechanisms are involved.
Title: Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations.
Our results indicate an important role of DSCAM and DSCAML1 in the development of cortical neural network.
Title: DSCAM and DSCAML1 regulate the radial migration and callosal projection in developing cerebral cortex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224779

d8mgh12 (e-PCR)
- UniSTS:122389

NoName (e-PCR)
- UniSTS:236117

D9Mit192 (e-PCR), detects polymorphism
- UniSTS:131749

C87679 (e-PCR)
- UniSTS:185787

RH70845 (e-PCR)
- UniSTS:19132

BB239540 (e-PCR)
- UniSTS:185788

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISO Inferred from Sequence Orthology more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule DSCAML1

Names: Down syndrome cell adhesion molecule like 1; Down syndrome cell adhesion molecule-like protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081270.2 → NP_001074739.2 cell adhesion molecule DSCAML1 precursor

Status: VALIDATED

Source sequence(s)

AC119237, AC126804, AC159893, AC174644

Consensus CDS

CCDS40608.1

UniProtKB/Swiss-Prot

Q4VA61

UniProtKB/TrEMBL

E9QPR7

Related

ENSMUSP00000034592.10, ENSMUST00000034592.11

Conserved Domains (7) summary

cd05734
Location:707 → 785

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:519 → 577

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1384 → 1474

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:1307 → 1377

Ig; Immunoglobulin domain

pfam07679
Location:226 → 311

I-set; Immunoglobulin I-set domain

pfam13927
Location:317 → 389

Ig_3; Immunoglobulin domain

cl11960
Location:803 → 891

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

45338735..45665011

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313109.2 → XP_017168598.1 cell adhesion molecule DSCAML1 isoform X2

UniProtKB/TrEMBL

E9QPR7

Conserved Domains (8) summary

cd05734
Location:571 → 649

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:383 → 441

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1248 → 1338

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:1171 → 1241

Ig; Immunoglobulin domain

pfam00041
Location:957 → 1040

fn3; Fibronectin type III domain

pfam07679
Location:97 → 175

I-set; Immunoglobulin I-set domain

pfam13927
Location:181 → 253

Ig_3; Immunoglobulin domain

cl11960
Location:667 → 755

Ig; Immunoglobulin domain
XM_006509947.3 → XP_006510010.1 cell adhesion molecule DSCAML1 isoform X1

UniProtKB/TrEMBL

E9QPR7

Conserved Domains (8) summary

cd05734
Location:666 → 744

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:478 → 536

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1343 → 1433

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:1266 → 1336

Ig; Immunoglobulin domain

pfam00041
Location:1170 → 1233

fn3; Fibronectin type III domain

pfam07679
Location:291 → 369

I-set; Immunoglobulin I-set domain

pfam13927
Location:375 → 447

Ig_3; Immunoglobulin domain

cl11960
Location:762 → 850

Ig; Immunoglobulin domain
XM_036154570.1 → XP_036010463.1 cell adhesion molecule DSCAML1 isoform X3

UniProtKB/TrEMBL

Q8CHB2

Conserved Domains (7) summary

cd00063
Location:874 → 964

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:583 → 669

fn3; Fibronectin type III domain

pfam13927
Location:781 → 857

Ig_3; Immunoglobulin domain

cd00096
Location:3 → 7

Ig; Ig strand A' [structural motif]

cd05734
Location:179 → 275

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:276 → 376

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:1 → 83

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_029039.2: Suppressed sequence

Description

NM_029039.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.