Prss1l serine protease 1 (trypsin 1) like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss1lprovided by MGI
Official Full Name: serine protease 1 (trypsin 1) likeprovided by MGI
Primary source: MGI:MGI:3646222
See related: Ensembl:ENSMUSG00000058119 AllianceGenome:MGI:3646222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm5771; EG436523
Summary: Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human PRSS3P2 (PRSS3 pseudogene 2); PRSS1 (serine protease 1); and PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 6 B1; 6 19.52 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (41369290..41374190)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (41392356..41397256)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trypsinogen 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_006980.1

Range

501562..506462

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038997.2 → NP_001034086.1 trypsinogen 12 precursor

See identical proteins and their annotated locations for NP_001034086.1

Status: VALIDATED

Source sequence(s)

AC158659

Consensus CDS

CCDS20048.1

UniProtKB/TrEMBL

B9EJ35, Q792Y9

Related

ENSMUSP00000039684.8, ENSMUST00000049079.9

Conserved Domains (2) summary

smart00020
Location:22 → 238

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:23 → 241

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...