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    Os9 amplified in osteosarcoma [ Mus musculus (house mouse) ]

    Gene ID: 216440, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Os9provided by MGI
    Official Full Name
    amplified in osteosarcomaprovided by MGI
    Primary source
    MGI:MGI:1924301
    See related
    Ensembl:ENSMUSG00000040462 AllianceGenome:MGI:1924301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632413K17Rik
    Summary
    Predicted to enable protease binding activity. Predicted to be involved in several processes, including negative regulation of retrograde protein transport, ER to cytosol; protein retention in ER lumen; and proteolysis involved in protein catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human OS9 (OS9 endoplasmic reticulum lectin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 33.8), liver adult (RPKM 33.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Os9 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (126928880..126957029, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127094259..127121160, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:126500339-126500526 Neighboring gene RIKEN cDNA A730063M14 gene Neighboring gene STARR-positive B cell enhancer ABC_E582 Neighboring gene cyclin dependent kinase 4 Neighboring gene tetraspanin 31 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 Neighboring gene predicted gene, 40799 Neighboring gene STARR-positive B cell enhancer ABC_E253 Neighboring gene STARR-seq mESC enhancer starr_28206 Neighboring gene STARR-seq mESC enhancer starr_28208 Neighboring gene coenzyme Q4 homolog pseudogene Neighboring gene predicted gene, 23664

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage. Yu L, et al. Mol Med Rep, 2011 Jul-Aug. PMID 21523322
    2. The endoplasmic reticulum-associated protein, OS-9, behaves as a lectin in targeting the immature calcium-sensing receptor. Ward BK, et al. J Cell Physiol, 2018 Jan. PMID 28419469
    3. Ca2(+)-dependent interaction of N-copine, a member of the two C2 domain protein family, with OS-9, the product of a gene frequently amplified in osteosarcoma. Nakayama T, et al. FEBS Lett, 1999 Jun 18. PMID 10403379
    4. OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway. Seaayfan E, et al. J Biol Chem, 2016 Feb 26. PMID 26721884, Free PMC Article
    5. A selective interaction between OS-9 and the carboxyl-terminal tail of meprin beta. Litovchick L, et al. J Biol Chem, 2002 Sep 13. PMID 12093806

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1) prior to glycosylation/processing.
      Title: OS9 Protein Interacts with Na-K-2Cl Co-transporter (NKCC2) and Targets Its Immature Form for the Endoplasmic Reticulum-associated Degradation Pathway.
    2. The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation.
      Title: Osteosarcoma amplified 9 is highly expressed in mouse adipocytes and controls lipid storage.
    3. OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation.
      Title: OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein retention in ER lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein retention in ER lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein OS-9
    Names
    osteosarcoma amplified 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171026.1 → NP_001164497.1  protein OS-9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001164497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131760, AK028047, BF470029, CD802565, DV647242
      Consensus CDS
      CCDS48713.1
      UniProtKB/Swiss-Prot
      Q8K2C7
      UniProtKB/TrEMBL
      Q922S5
      Related
      ENSMUSP00000128914.2, ENSMUST00000164259.9
      Conserved Domains (2) summary
      pfam07915
      Location:110 → 181
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:175 → 236
      PRKCSH; Glucosidase II beta subunit-like protein

    2. NM_177614.3 → NP_808282.2  protein OS-9 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is a shorter, compared to isoform 1.
      Source sequence(s)
      AC131760, BF470029, BU703218, BY297242, CD802565, CX566458, DV660362
      Consensus CDS
      CCDS24229.1
      UniProtKB/TrEMBL
      Q922S5
      Related
      ENSMUSP00000079770.5, ENSMUST00000080975.6
      Conserved Domains (2) summary
      pfam07915
      Location:110 → 181
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:175 → 236
      PRKCSH; Glucosidase II beta subunit-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      126928880..126957029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245044.2 → XP_030100904.1  protein OS-9 isoform X2

      UniProtKB/TrEMBL
      Q922S5
      Conserved Domains (1) summary
      pfam07915
      Location:6 → 77
      PRKCSH; Glucosidase II beta subunit-like protein

    2. XM_011243420.2 → XP_011241722.1  protein OS-9 isoform X1

      UniProtKB/TrEMBL
      Q922S5
      Conserved Domains (2) summary
      PTZ00121
      Location:155 → 545
      PTZ00121; MAEBL; Provisional
      pfam07915
      Location:6 → 77
      PRKCSH; Glucosidase II beta subunit-like protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2C7.2 GenPept UniProtKB/Swiss-Prot:Q8K2C7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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