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    Plek2 pleckstrin 2 [ Mus musculus (house mouse) ]

    Gene ID: 27260, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plek2provided by MGI
    Official Full Name
    pleckstrin 2provided by MGI
    Primary source
    MGI:MGI:1351466
    See related
    Ensembl:ENSMUSG00000021118 AllianceGenome:MGI:1351466
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables phosphatidylinositol-3,4-bisphosphate binding activity; phosphatidylinositol-3,5-bisphosphate binding activity; and phosphatidylinositol-3-phosphate binding activity. Involved in actin cytoskeleton organization and positive regulation of plasma membrane bounded cell projection assembly. Acts upstream of or within positive regulation of cell projection organization. Located in membrane. Is active in plasma membrane. Orthologous to human PLEK2 (pleckstrin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14.5 (RPKM 12.3), liver E14 (RPKM 12.0) and 11 other tissues See more
    Orthologs
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    Genomic context

    See Plek2 in Genome Data Viewer
    Location:
    12 C3; 12 35.51 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (78935465..78955166, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78888691..78907172, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32577 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene STARR-seq mESC enhancer starr_32578 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha Neighboring gene STARR-seq mESC enhancer starr_32580 Neighboring gene predicted gene, 46359 Neighboring gene STARR-seq mESC enhancer starr_32581 Neighboring gene predicted gene, 46360 Neighboring gene transmembrane protein 229B Neighboring gene STARR-seq mESC enhancer starr_32582 Neighboring gene STARR-seq mESC enhancer starr_32583

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lamellipodium membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013738.3NP_038766.1  pleckstrin-2

      See identical proteins and their annotated locations for NP_038766.1

      Status: PROVISIONAL

      Source sequence(s)
      BC028902
      Consensus CDS
      CCDS26004.1
      UniProtKB/Swiss-Prot
      Q9WV52
      Related
      ENSMUSP00000021544.8, ENSMUST00000021544.8
      Conserved Domains (4) summary
      cd04444
      Location:128236
      DEP_PLEK2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins. Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central ...
      cd13301
      Location:3113
      PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
      cd13302
      Location:243353
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:595
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      78935465..78955166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157436.1XP_036013329.1  pleckstrin-2 isoform X2

      Conserved Domains (2) summary
      cd13302
      Location:108218
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      cl02442
      Location:1101
      DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
    2. XM_006515934.4XP_006515997.1  pleckstrin-2 isoform X1

      Conserved Domains (3) summary
      cd04444
      Location:73181
      DEP_PLEK2; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 2-like proteins. Pleckstrin 2 is found in a wide variety of cell types, which suggest a more general role in signaling than pleckstrin 1. Pleckstrin-like proteins contain a central ...
      cd13302
      Location:188298
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      cl17171
      Location:1358
      PH-like; Pleckstrin homology-like domain