Mapk12 mitogen-activated protein kinase 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk12provided by MGI
Official Full Name: mitogen-activated protein kinase 12provided by MGI
Primary source: MGI:MGI:1353438
See related: Ensembl:ENSMUSG00000022610 AllianceGenome:MGI:1353438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Erk6; Sapk3; Prkm12; P38gamma
Summary: Predicted to enable ATP binding activity; MAP kinase activity; and magnesium ion binding activity. Predicted to be involved in several processes, including myoblast differentiation; negative regulation of cell cycle; and peptidyl-serine phosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in cap mesenchyme; cerebral cortex ventricular layer; lung mesenchyme; metanephros; and olfactory epithelium. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cerebellum adult (RPKM 12.5), bladder adult (RPKM 9.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E3; 15 44.65 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (89014787..89025270, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (89130584..89141577, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p38gamma and p38delta modulate innate immune response by regulating MEF2D activation.
Title: p38γ and p38δ modulate innate immune response by regulating MEF2D activation.
Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
Title: Effect of Thyroxine on the Structural and Dynamic Features of Cardiac Mitochondria and Mitophagy in Rats.
The pro-tumorigenic activity of p38gamma overexpression in nasopharyngeal carcinoma.
Title: The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma.
p38gamma and p38delta regulate postnatal cardiac metabolism through glycogen synthase 1.
Title: p38γ and p38δ regulate postnatal cardiac metabolism through glycogen synthase 1.
In mouse hepatocytes, p38gamma induces proliferation after partial hepatectomy by promoting the phosphorylation of retinoblastoma tumour suppressor protein at known CDK target residues. Lack of p38gamma or treatment with the p38gamma inhibitor pirfenidone protects against the chemically induced formation of liver tumours.
Title: p38γ is essential for cell cycle progression and liver tumorigenesis.
Mitogen-activated protein kinases p38gamma/p38delta deficiency protects against Candida albicans infection by increasing reactive oxygen species and iNOS enzyme production and thus the antifungal capacity of neutrophils and macrophages.
Title: Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
p38gamma mitogen-activated protein kinase mediates inflammatory signaling to promote colon tumorigenesis
Title: p38γ MAPK is required for inflammation-associated colon tumorigenesis.
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy
Title: p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.
p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
Title: p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.
Findings provide genetic evidence that p38gamma and p38delta have essential roles in skin tumour development.
Title: Combined deletion of p38γ and p38δ reduces skin inflammation and protects from carcinogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mapk12 (e-PCR), detects polymorphism
- UniSTS:527414

AW123708 (e-PCR)
- UniSTS:180817

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mitogen-activated protein kinase 12

Names: ERK-6; MAP kinase 12; MAP kinase p38 gamma; MAPK 12; extracellular signal-regulated kinase 6; mitogen-activated protein kinase p38 gamma; stress-activated protein kinase 3

NP_001389948.1

EC 2.7.11.24

NP_001389949.1

EC 2.7.11.24

NP_001389950.1

EC 2.7.11.24

NP_001389951.1

EC 2.7.11.24

NP_038899.1

EC 2.7.11.24

XP_006521121.1

EC 2.7.11.24

XP_006521122.1

EC 2.7.11.24

XP_006521124.1

EC 2.7.11.24

XP_036015349.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403019.1 → NP_001389948.1 mitogen-activated protein kinase 12 isoform 2

Status: VALIDATED

Source sequence(s)

AC113069
NM_001403020.1 → NP_001389949.1 mitogen-activated protein kinase 12 isoform 3

Status: VALIDATED

Source sequence(s)

AC113069
NM_001403021.1 → NP_001389950.1 mitogen-activated protein kinase 12 isoform 4

Status: VALIDATED

Source sequence(s)

AC113069
NM_001403022.1 → NP_001389951.1 mitogen-activated protein kinase 12 isoform 4

Status: VALIDATED

Source sequence(s)

AC113069
NM_013871.4 → NP_038899.1 mitogen-activated protein kinase 12 isoform 1

See identical proteins and their annotated locations for NP_038899.1

Status: VALIDATED

Source sequence(s)

AC113069

Consensus CDS

CCDS27740.1

UniProtKB/Swiss-Prot

O08911, Q9D0M4

Related

ENSMUSP00000086207.7, ENSMUST00000088827.8

Conserved Domains (1) summary

cd07880
Location:11 → 353

STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

89014787..89025270 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159456.1 → XP_036015349.1 mitogen-activated protein kinase 12 isoform X2

Conserved Domains (1) summary

cl21453
Location:11 → 366

PKc_like; Protein Kinases, catalytic domain
XM_006521059.5 → XP_006521122.1 mitogen-activated protein kinase 12 isoform X3

Conserved Domains (1) summary

cl21453
Location:11 → 360

PKc_like; Protein Kinases, catalytic domain
XM_006521058.5 → XP_006521121.1 mitogen-activated protein kinase 12 isoform X1

Conserved Domains (1) summary

cd07880
Location:11 → 376

STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)
XM_006521061.5 → XP_006521124.1 mitogen-activated protein kinase 12 isoform X6

Conserved Domains (1) summary

cl21453
Location:1 → 195

PKc_like; Protein Kinases, catalytic domain