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    Man2c1 mannosidase, alpha, class 2C, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Man2c1provided by RGD
    Official Full Name
    mannosidase, alpha, class 2C, member 1provided by RGD
    Primary source
    RGD:628787
    See related
    EnsemblRapid:ENSRNOG00000030654 AllianceGenome:RGD:628787
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AMAN
    Summary
    Enables alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 195.5), Adrenal (RPKM 169.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Man2c1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66434480..66445649)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57537879..57549691)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61805697..61816800)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094171 Neighboring gene SIN3 transcription regulator family member A Neighboring gene uncharacterized LOC120094172 Neighboring gene nei-like DNA glycosylase 1 Neighboring gene COMM domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization, and expression of cDNA encoding a rat liver endoplasmic reticulum alpha-mannosidase. Bischoff J, et al. J Biol Chem, 1990 Oct 5. PMID 2211613
    2. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93158

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligosaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-mannosidase 2C1
    Names
    alpha-D-mannoside mannohydrolase
    NP_640349.2
    XP_038936749.1
    XP_038936750.1
    XP_038936752.1
    XP_063120986.1
    XP_063120987.1
    XP_063120988.1
    XP_063120989.1
    XP_063120990.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139256.2 → NP_640349.2  alpha-mannosidase 2C1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      F1LPQ3, Q5M9I2
      Related
      ENSRNOP00000041867.5, ENSRNOT00000048318.7
      Conserved Domains (2) summary
      cd10813
      Location:251 → 502
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:67 → 1034
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66434480..66445649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264920.1 → XP_063120990.1  alpha-mannosidase 2C1 isoform X8

      UniProtKB/TrEMBL
      F1LPQ3

    2. XM_063264916.1 → XP_063120986.1  alpha-mannosidase 2C1 isoform X1

      UniProtKB/TrEMBL
      F1LPQ3

    3. XM_063264917.1 → XP_063120987.1  alpha-mannosidase 2C1 isoform X2

      UniProtKB/TrEMBL
      F1LPQ3

    4. XM_039080821.2 → XP_038936749.1  alpha-mannosidase 2C1 isoform X3

      UniProtKB/TrEMBL
      F1LPQ3
      Related
      ENSRNOP00000110370.1, ENSRNOT00000171959.1
      Conserved Domains (2) summary
      cd10813
      Location:277 → 528
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:93 → 1008
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    5. XM_063264919.1 → XP_063120989.1  alpha-mannosidase 2C1 isoform X6

      UniProtKB/TrEMBL
      A6J4S7

    6. XM_039080824.2 → XP_038936752.1  alpha-mannosidase 2C1 isoform X7

      Conserved Domains (2) summary
      cd10813
      Location:277 → 528
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:93 → 625
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]

    7. XM_063264918.1 → XP_063120988.1  alpha-mannosidase 2C1 isoform X4

      UniProtKB/TrEMBL
      F1LPQ3

    8. XM_039080822.2 → XP_038936750.1  alpha-mannosidase 2C1 isoform X5

      UniProtKB/TrEMBL
      F1LPQ3
      Conserved Domains (2) summary
      cd10813
      Location:189 → 440
      GH38N_AMII_Man2C1; N-terminal catalytic domain of mammalian cytosolic alpha-mannosidase Man2C1 and similar proteins; glycoside hydrolase family 38 (GH38)
      COG0383
      Location:190 → 972
      AMS1; Alpha-mannosidase [Carbohydrate transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21139.1 GenPept UniProtKB/Swiss-Prot:P21139

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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