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    Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305367, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Arap2provided by RGD
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2provided by RGD
    Primary source
    RGD:1306452
    See related
    EnsemblRapid:ENSRNOG00000056826 AllianceGenome:RGD:1306452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Centd1
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to be active in cytoplasm. Orthologous to human ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 199.5), Lung (RPKM 180.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arap2 in Genome Data Viewer
    Location:
    14q11
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (50921323..51120972)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (46717657..46917326)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (48726033..48922809)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transformer 2 beta, pseudogene 1 Neighboring gene death domain containing 1 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene actin related protein 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Krugmann S, et al. Mol Cell, 2002 Jan. PMID 11804589
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
    Names
    centaurin, delta 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107216.1 → NP_001100686.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

      See identical proteins and their annotated locations for NP_001100686.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473963
      UniProtKB/TrEMBL
      A0A0G2K7I9, A6IJD8
      Conserved Domains (7) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1110 → 1289
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17227
      Location:1298 → 1395
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1401 → 1512
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      50921323..51120972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091929.2 → XP_038947857.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

      Conserved Domains (7) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1110 → 1289
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17227
      Location:1335 → 1432
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1438 → 1549
      PH-like; Pleckstrin homology-like domain

    2. XM_039091938.2 → XP_038947866.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X7

      Conserved Domains (4) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2

    3. XM_039091932.2 → XP_038947860.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X4

      Conserved Domains (7) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1110 → 1289
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17227
      Location:1335 → 1432
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:888 → 998
      PH-like; Pleckstrin homology-like domain

    4. XM_039091937.2 → XP_038947865.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X6

      Conserved Domains (5) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:888 → 996
      PH-like; Pleckstrin homology-like domain

    5. XM_039091927.2 → XP_038947855.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

      Related
      ENSRNOP00000103220.1, ENSRNOT00000164131.1
      Conserved Domains (7) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1110 → 1289
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17227
      Location:1335 → 1432
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1438 → 1549
      PH-like; Pleckstrin homology-like domain

    6. XM_039091930.2 → XP_038947858.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A096MK16
      Related
      ENSRNOP00000070433.2, ENSRNOT00000082599.3
      Conserved Domains (7) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1110 → 1289
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17227
      Location:1321 → 1418
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1424 → 1535
      PH-like; Pleckstrin homology-like domain

    7. XM_039091931.2 → XP_038947859.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K7I9, A6IJD8
      Related
      ENSRNOP00000074225.2, ENSRNOT00000086646.3
      Conserved Domains (7) summary
      cd09490
      Location:6 → 68
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:1110 → 1289
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:480 → 571
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:581 → 671
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17227
      Location:1298 → 1395
      RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
      cd08856
      Location:676 → 796
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:1401 → 1512
      PH-like; Pleckstrin homology-like domain

    8. XM_039091936.2 → XP_038947864.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X5

      Conserved Domains (5) summary
      cd04385
      Location:604 → 783
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13254
      Location:75 → 165
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd08856
      Location:170 → 290
      ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
      cl17171
      Location:932 → 1043
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:829 → 926
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RNA

    1. XR_005492952.2 RNA Sequence

    2. XR_005492953.2 RNA Sequence

    3. XR_010057366.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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