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    Cd99l2 CD99 antigen-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 171486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd99l2provided by MGI
    Official Full Name
    CD99 antigen-like 2provided by MGI
    Primary source
    MGI:MGI:2177151
    See related
    Ensembl:ENSMUSG00000035776 AllianceGenome:MGI:2177151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xap89; Mic2l1
    Summary
    Acts upstream of or within diapedesis; positive regulation of T cell extravasation; and positive regulation of neutrophil extravasation. Located in adherens junction and cell surface. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and skin. Orthologous to human CD99L2 (CD99 molecule like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 23.1), whole brain E14.5 (RPKM 17.7) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd99l2 in Genome Data Viewer
    Location:
    X A7.3; X 36.82 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (70463666..70536467, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (71420060..71492866, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7692 Neighboring gene STARR-seq mESC enhancer starr_47322 Neighboring gene X-linked myotubular myopathy gene 1 Neighboring gene myotubularin related protein 1 Neighboring gene STARR-seq mESC enhancer starr_47323 Neighboring gene STARR-seq mESC enhancer starr_47324 Neighboring gene ribosomal protein L36 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:68808842-68809143 Neighboring gene high mobility group box 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. Samus M, et al. J Leukoc Biol, 2018 Oct. PMID 29791026
    2. CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response. Rutledge NS, et al. Exp Mol Pathol, 2015 Dec. PMID 26321243, Free PMC Article
    3. Effect of shRNA targeting mouse CD99L2 gene in a murine B cell lymphoma in vitro and in vivo. Liu F, et al. Oncol Rep, 2013 Apr. PMID 23338758
    4. [Expression and cloning of mCD99L2 gene from mouse B lymphoma cell line A20 and construction of its eukaryotic expression vector]. Shen LJ, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2006 Feb. PMID 16503515
    5. Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. Seelige R, et al. J Immunol, 2013 Feb 1. PMID 23293350

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conditional Tie-2-Cre driven gene inactivation of CD99L2 inhibits leukocyte entry into the CNS during active MOG35-55 -induced experimental autoimmune encephalomyelitis and alleviates severity of the disease. CD99L2 participates in the development of EAE by supporting diapedesis of leukocytes through the endothelial basement membrane of blood vessels of the BBB in the CNS.
      Title: CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation.
    2. Mice lacking CD99L2 had a defective inflammatory response in the thioglycollate peritonitis model
      Title: CD99-like 2 (CD99L2)-deficient mice are defective in the acute inflammatory response.
    3. The present study provides data for further investigation into the mCD99L2 gene in tumor cells.
      Title: Effect of shRNA targeting mouse CD99L2 gene in a murine B cell lymphoma in vitro and in vivo.
    4. CD99L2 is an essential endothelial Ag for leukocyte extravasation, which does not require homophilic interactions with CD99L2 on leukocytes.
      Title: Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo.
    5. Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo.
      Title: The murine CD99-related molecule CD99-like 2 (CD99L2) is an adhesion molecule involved in the inflammatory response.
    6. expressed on mouse leukocytes and endothelial cells and is involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum
      Title: A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within diapedesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of T cell extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of neutrophil extravasation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    CD99 antigen-like protein 2
    Names
    MIC2 (monoclonal Imperial Cancer Research Fund 2)-like 1
    MIC2 like-1
    MIC2-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199349.1 → NP_001186278.1  CD99 antigen-like protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001186278.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AK080225, BF147574, BY727540
      Consensus CDS
      CCDS57761.1
      UniProtKB/Swiss-Prot
      A2AP77, Q8BIF0, Q8R447
      UniProtKB/TrEMBL
      A2AP74
      Related
      ENSMUSP00000042606.6, ENSMUST00000037391.12
      Conserved Domains (1) summary
      pfam12301
      Location:30 → 215
      CD99L2; CD99 antigen like protein 2

    2. NM_138309.3 → NP_612182.1  CD99 antigen-like protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_612182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK080225, AY078163, BF147574, BY727540
      Consensus CDS
      CCDS30179.1
      UniProtKB/TrEMBL
      I7HJQ8
      Related
      ENSMUSP00000078944.5, ENSMUST00000080035.11
      Conserved Domains (1) summary
      pfam12301
      Location:30 → 192
      CD99L2; CD99 antigen like protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      70463666..70536467 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527887.5 → XP_006527950.1  CD99 antigen-like protein 2 isoform X2

      UniProtKB/TrEMBL
      I7HJQ8
      Conserved Domains (1) summary
      pfam12301
      Location:30 → 198
      CD99L2; CD99 antigen like protein 2

    2. XM_006527886.5 → XP_006527949.1  CD99 antigen-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A2AP74
      Conserved Domains (1) summary
      pfam12301
      Location:30 → 221
      CD99L2; CD99 antigen like protein 2

    3. XM_011247540.3 → XP_011245842.1  CD99 antigen-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011245842.1

      Conserved Domains (2) summary
      pfam12301
      Location:65 → 144
      CD99L2; CD99 antigen like protein 2
      cl19816
      Location:24 → 71
      Hydantoinase_B; Hydantoinase B/oxoprolinase

    4. XM_017318407.3 → XP_017173896.1  CD99 antigen-like protein 2 isoform X4

      Conserved Domains (2) summary
      pfam12301
      Location:65 → 138
      CD99L2; CD99 antigen like protein 2
      cl19816
      Location:24 → 71
      Hydantoinase_B; Hydantoinase B/oxoprolinase

    5. XM_011247541.3 → XP_011245843.1  CD99 antigen-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011245843.1

      Conserved Domains (2) summary
      pfam12301
      Location:65 → 144
      CD99L2; CD99 antigen like protein 2
      cl19816
      Location:24 → 71
      Hydantoinase_B; Hydantoinase B/oxoprolinase

    6. XM_011247542.4 → XP_011245844.1  CD99 antigen-like protein 2 isoform X3

      See identical proteins and their annotated locations for XP_011245844.1

      Conserved Domains (2) summary
      pfam12301
      Location:65 → 144
      CD99L2; CD99 antigen like protein 2
      cl19816
      Location:24 → 71
      Hydantoinase_B; Hydantoinase B/oxoprolinase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIF0.1 GenPept UniProtKB/Swiss-Prot:Q8BIF0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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