Baiap2l1 BAI1-associated protein 2-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Baiap2l1provided by MGI
Official Full Name: BAI1-associated protein 2-like 1provided by MGI
Primary source: MGI:MGI:1914148
See related: Ensembl:ENSMUSG00000038859 AllianceGenome:MGI:1914148
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IRTKS; 1300006M19Rik
Summary: Predicted to enable proline-rich region binding activity. Predicted to be involved in actin crosslink formation; actin filament bundle assembly; and positive regulation of actin filament polymerization. Predicted to be located in plasma membrane. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with actin cytoskeleton. Is expressed in several structures, including brain; gut; lung; and nose. Orthologous to human BAIAP2L1 (BAR/IMD domain containing adaptor protein 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in colon adult (RPKM 37.6), stomach adult (RPKM 27.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 83.24 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (144201335..144294922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (144264525..144358112, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence.
Title: Heterochromatin formation and remodeling by IRTKS condensates counteract cellular senescence.
BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology.
Title: BAIAP2L1 and BAIAP2L2 differently regulate hair cell stereocilia morphology.
IRTKS localizes to the distal tips of actively growing microvilli via a mechanism that requires its N-terminal I-BAR domain. At microvillar tips, IRTKS promotes elongation through a mechanism involving its C-terminal actin-binding WH2 domain.
Title: IRTKS (BAIAP2L1) Elongates Epithelial Microvilli Using EPS8-Dependent and Independent Mechanisms.
double knockout of IRSp53 and its closest family member, IRTKS, resulted in exacerbated placental abnormalities, particularly in spongiotrophoblast differentiation and development, giving rise to complete embryonic lethality.
Title: Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development.
Rho family GTPases use the I-BAR proteins, IRSp53 (also known as BAIAP2), IRTKS and Pinkbar, as a central mechanism to modulate cell morphology.
Title: The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia.
The IRTKS, as an adaptor of the insulin receptor (IR), modulates IR-IRS1-PI3K-AKT signaling via regulating the phosphorylation of IR.
Title: Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance.
IRTKS functions as a negative modulator of excessive inflammation in viral infections.
Title: IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC343294P1 (e-PCR)
- UniSTS:273189

PMC133845P3 (e-PCR)
- UniSTS:270670

PMC350564P1 (e-PCR)
- UniSTS:273240

PMC152246P1 (e-PCR)
- UniSTS:271203

PMC123151P1 (e-PCR)
- UniSTS:270439

AI585895 (e-PCR)
- UniSTS:179315

PMC18810P1 (e-PCR)
- UniSTS:271733

PMC140912P1 (e-PCR)
- UniSTS:270982

RH124597 (e-PCR)
- UniSTS:161419

PMC153210P1 (e-PCR)
- UniSTS:271251

UniSTS:530589 (e-PCR)
- UniSTS:530589

Rn18s (e-PCR), detects polymorphism
- UniSTS:530589

RH125423 (e-PCR)
- UniSTS:162245

D5Mit377 (e-PCR), detects polymorphism
- UniSTS:130531

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: BAR/IMD domain-containing adapter protein 2-like 1

Names: BAI1-associated protein 2-like protein 1; brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; insulin receptor tyrosine kinase substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025833.3 → NP_080109.1 BAR/IMD domain-containing adapter protein 2-like 1

See identical proteins and their annotated locations for NP_080109.1

Status: VALIDATED

Source sequence(s)

AK004918, AV224233

Consensus CDS

CCDS39378.1

UniProtKB/Swiss-Prot

Q9DBJ3

Related

ENSMUSP00000053129.8, ENSMUST00000055190.8

Conserved Domains (2) summary

cd07645
Location:6 → 231

I-BAR_IMD_BAIAP2L1; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1

cd11913
Location:343 → 400

SH3_BAIAP2L1; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 1, also called Insulin Receptor Tyrosine Kinase Substrate (IRTKS)