Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsd17b4provided by RGD
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 4provided by RGD
Primary source: RGD:621806
See related: EnsemblRapid:ENSRNOG00000015840 AllianceGenome:RGD:621806
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MFP-2; MPF-2
Summary: Enables 3-hydroxyacyl-CoA dehydratase activity; identical protein binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in cellular response to organic cyclic compound; response to steroid hormone; and response to xenobiotic stimulus. Located in peroxisome. Biomarker of hypertension. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1658.1), Kidney (RPKM 1029.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (45515427..45604467)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (43328903..43417950)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (44810462..44897677)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HSD17B4 is over-expressed in rat liver cancer tissues. Its expression was positively correlated with TNF-alpha, IL-6 and PCNA levels.
Title: Correlation between HSD17B4 expression in rat liver cancer tissues and inflammation or proliferation.
Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility
Title: Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxyacyl-CoA dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3-hydroxyacyl-CoA dehydratase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxyacyl-CoA dehydratase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity	IEA Inferred from Electronic Annotation more info
enables enoyl-CoA hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enoyl-CoA hydratase activity	ISO Inferred from Sequence Orthology more info
enables enoyl-CoA hydratase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase [NAD(P)+] activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Sertoli cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Sertoli cell development	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholesterol metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in estrogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in medium-chain fatty-acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in medium-chain fatty-acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in very long-chain fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in very long-chain fatty-acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty-acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxisomal multifunctional enzyme type 2

Names: 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; D-bifunctional protein; DBP; MFE-2; multifunctional protein 2; peroxisomal multifunctional enzyme type II

NP_077368.2

EC 1.1.1.n12

EC 4.2.1.107

EC 4.2.1.119

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024392.2 → NP_077368.2 peroxisomal multifunctional enzyme type 2

See identical proteins and their annotated locations for NP_077368.2

Status: VALIDATED

Source sequence(s)

BC072472, BM391394, U37486

UniProtKB/Swiss-Prot

P70523, P70540, P97852

UniProtKB/TrEMBL

Q6IN39

Related

ENSRNOP00000081103.2, ENSRNOT00000115693.2

Conserved Domains (6) summary

PLN02864
Location:326 → 604

PLN02864; enoyl-CoA hydratase

cd05353
Location:5 → 254

hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs

PRK05653
Location:6 → 226

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated

cd03448
Location:484 → 604

HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.

pfam02036
Location:627 → 730

SCP2; SCP-2 sterol transfer family

cl00509
Location:394 → 437

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...