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    RCH1 Rch1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RCH1
    Official Full Name
    Rch1p
    Primary source
    SGD:S000004637
    Locus tag
    YMR034C
    See related
    AllianceGenome:SGD:S000004637; FungiDB:YMR034C; VEuPathDB:YMR034C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in negative regulation of cytosolic calcium ion concentration. Located in cellular bud neck and plasma membrane. Used to study amelogenesis imperfecta; osteochondrodysplasia; and osteoporosis. Orthologous to human SLC10A7 (solute carrier family 10 member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RCH1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (339418..340722, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Arp9p Neighboring gene endopeptidase catalytic subunit Neighboring gene putative tyrosine protein phosphatase MIH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Calmodulin kinase 2 genetically interacts with Rch1p to negatively regulate calcium import into Saccharomyces cerevisiae after extracellular calcium pulse. Coleman CE, et al. Arch Microbiol, 2022 Jul 24. PMID 35871646
    2. Genetic analysis of azole resistance by transposon mutagenesis in Saccharomyces cerevisiae. Kontoyiannis DP. Antimicrob Agents Chemother, 1999 Nov. PMID 10543755, Free PMC Article
    3. The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast. Zhao Y, et al. Eur J Cell Biol, 2016 Mar-May. PMID 26832117
    4. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Godoy JR, et al. Eur J Cell Biol, 2007 Aug. PMID 17628207
    5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Saccharomyces cerevisiae Rch1 distribute as multiple foci in the plasma membrane prior to cell division, move toward and concentrate at the bud neck as the bud grows in size, and disperse again along the plasma membrane immediately prior to cytokinesis.
      Title: The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monocarboxylic acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cytosolic calcium ion concentration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rch1p
    NP_013748.1
    • Negative regulator of cytosolic calcium homeostasis; localizes to the plasma membrane, concentrating at the bud neck during cell division; regulated by Crz1p through a CDRE promoter element; non-essential gene; putative transporter with sequence similarity to human SLC10A7; functional homolog of C. albicans RCH1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      339418..340722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182531.1 → NP_013748.1  TPA: Rch1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013748.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZK9, Q05131
      UniProtKB/TrEMBL
      B3LLT3, B5VPG3, C7GL85, C8ZEP1, N1P5D3
      Conserved Domains (1) summary
      pfam13593
      Location:23 → 385
      SBF_like; SBF-like CPA transporter family (DUF4137)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05131.1

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