Spint1 serine peptidase inhibitor, Kunitz type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spint1provided by RGD
Official Full Name: serine peptidase inhibitor, Kunitz type 1provided by RGD
Primary source: RGD:1303138
See related: EnsemblRapid:ENSRNOG00000012811 AllianceGenome:RGD:1303138
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HAI-1
Summary: Enables serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus; negative regulation of neural precursor cell proliferation; and positive regulation of glial cell differentiation. Predicted to be active in plasma membrane. Biomarker of liver cirrhosis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 164.7), Kidney (RPKM 133.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (126685017..126697957)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (106231082..106244121)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (111049132..111061991)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign
Title: Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1.
Title: Identification of the matriptase second CUB domain as the secondary site for interaction with hepatocyte growth factor activator inhibitor type-1.
The N-terminal domain and Kunitz domain II decreased the association rate between Kunitz domain I and matriptase, whereas the internal domain increased this rate.
Title: Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in epidermis development	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelium development	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within placenta blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kunitz-type protease inhibitor 1

Names: hepatocyte growth factor activator inhibitor-1; serine protease inhibitor, Kunitz type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004265.3 → NP_001004265.2 kunitz-type protease inhibitor 1 precursor

See identical proteins and their annotated locations for NP_001004265.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

F7ERY9, Q4V8Q2, Q6I750

Related

ENSRNOP00000017223.3, ENSRNOT00000017223.6

Conserved Domains (3) summary

smart00192
Location:313 → 344

LDLa; Low-density lipoprotein receptor domain class A

pfam00014
Location:368 → 420

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam07502
Location:42 → 133

MANEC; MANEC domain
NM_001433377.1 → NP_001420306.1 kunitz-type protease inhibitor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

F7ERY9, Q4V8Q2, Q6I750
NM_001433378.1 → NP_001420307.1 kunitz-type protease inhibitor 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

F7ERY9, Q4V8Q2, Q6I750

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

126685017..126697957

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006234764.4 → XP_006234826.1 kunitz-type protease inhibitor 1 isoform X1

Conserved Domains (3) summary

smart00192
Location:313 → 344

LDLa; Low-density lipoprotein receptor domain class A

pfam00014
Location:368 → 420

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam07502
Location:42 → 133

MANEC; MANEC domain
XM_006234763.4 → XP_006234825.1 kunitz-type protease inhibitor 1 isoform X1

Conserved Domains (3) summary

smart00192
Location:313 → 344

LDLa; Low-density lipoprotein receptor domain class A

pfam00014
Location:368 → 420

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam07502
Location:42 → 133

MANEC; MANEC domain