Rbbp7 RB binding protein 7, chromatin remodeling factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbbp7provided by RGD
Official Full Name: RB binding protein 7, chromatin remodeling factorprovided by RGD
Primary source: RGD:620125
See related: EnsemblRapid:ENSRNOG00000005157 AllianceGenome:RGD:620125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity and histone binding activity. Involved in response to steroid hormone. Predicted to be located in chromosome, telomeric region; cytosol; and nucleoplasm. Predicted to be part of ESC/E(Z) complex; NURF complex; and NuRD complex. Predicted to be active in nucleus. Orthologous to human RBBP7 (RB binding protein 7, chromatin remodeling factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 670.8), Thymus (RPKM 665.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (35544873..35563030, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (31913080..31931245, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (33648682..33665821, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endogenous Mta1/2 forms a complex with chromodomain helicase (Chd)4, histone deacetylase (Hdac)1/2, RbAp46/48, and Mbd3 in the rat cerebellum
Title: Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132537 (e-PCR)
- UniSTS:215820

AI173248 (e-PCR)
- UniSTS:181348

RH124898 (e-PCR)
- UniSTS:161720

RH136436 (e-PCR)
- UniSTS:210422

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in cellular heat acclimation	ISO Inferred from Sequence Orthology more info
involved_in cellular heat acclimation	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of ATPase complex	ISO Inferred from Sequence Orthology more info
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ESC/E(Z) complex	ISO Inferred from Sequence Orthology more info
part_of ESC/E(Z) complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NURF complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuRD complex	ISO Inferred from Sequence Orthology more info
part_of NuRD complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone deacetylase complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-binding protein RBBP7

Names: RBBP-7; nucleosome-remodeling factor subunit RBAP46; retinoblastoma-binding protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031816.2 → NP_114004.1 histone-binding protein RBBP7

See identical proteins and their annotated locations for NP_114004.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q71UF4

UniProtKB/TrEMBL

A0A8I6AQI0, A6K2N8

Related

ENSRNOP00000062148.1, ENSRNOT00000066676.3

Conserved Domains (3) summary

sd00039
Location:127 → 174

7WD40; WD40 repeat [structural motif]

pfam12265
Location:18 → 87

CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex

cl29593
Location:122 → 402

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...