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    SLC22A18AS SLC22A18 antisense RNA [ Homo sapiens (human) ]

    Gene ID: 5003, updated on 22-Oct-2024

    Summary

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    Official Symbol
    SLC22A18ASprovided by HGNC
    Official Full Name
    SLC22A18 antisense RNAprovided by HGNC
    Primary source
    HGNC:HGNC:10965
    See related
    Ensembl:ENSG00000254827 MIM:603240; AllianceGenome:HGNC:10965
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BWR1B; BWSCR1B; ORCTL2S; SLC22A1LS; p27-BWR1B
    Expression
    Broad expression in colon (RPKM 2.2), duodenum (RPKM 1.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SLC22A18AS in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (2887344..2903575, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (2976587..2992820, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2908574..2924805, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNQ1 downstream neighbor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2904223-2904722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2905995-2906830 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2906831-2907666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2907667-2908502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2913065-2913864 Neighboring gene cyclin dependent kinase inhibitor 1C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2924695-2925196 Neighboring gene solute carrier family 22 member 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2933345-2934048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2935457-2936158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2949927-2950535 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2950536-2951145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2951146-2951754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2954769-2955381 Neighboring gene pleckstrin homology like domain family A member 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:2961339-2961515 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2967017-2967632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:2967633-2968246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2968247-2968862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:2968863-2969476 Neighboring gene nucleosome assembly protein 1 like 4 Neighboring gene NANOG hESC enhancer GRCh37_chr11:2982073-2982579 Neighboring gene small nucleolar RNA, H/ACA box 54

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS. Bajaj V, et al. Gene, 2008 Nov 15. PMID 18721868
    2. Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5. Bajaj V, et al. BMC Genet, 2004 Jun 3. PMID 15175115, Free PMC Article
    3. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Cooper PR, et al. Genomics, 1998 Apr 1. PMID 9570947
    4. Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples. Schwienbacher C, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520460, Free PMC Article
    5. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. Meng X, et al. J Biol Chem, 2012 Feb 10. PMID 22199357, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC22A18/SLC22A18AS genes are a sense-antisense pair located at human chromosome segment 11p15.5. These genes are paternally imprinted.
      Title: Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS.
    2. Using antibodies generated in rabbit, immunoprecipitation and Western blot analyses, translation of a 253-aa ORF at very low levels occurred. The translated protein was mainly localized in the cytoplasm.
      Title: Promoter characterization and regulation of expression of an imprinted gene SLC22A18AS.
    3. Results suggest imprinting of the paternal allele of SLC22A1LS gene in five fetal tissues: brain, liver, placenta, kidneys and lungs.
      Title: Paternal imprinting of the SLC22A1LS gene located in the human chromosome segment 11p15.5.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • Beckwith-Wiedemann region 1B
    • Beckwith-Wiedemann syndrome chromosome region 1, candidate b
    • SLC22A18-AS1
    • beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein
    • organic cation transporter-like 2 antisense
    • organic cation transporter-like protein 2 antisense protein
    • p27-Beckwith-Wiedemann region 1 B
    • solute carrier family 22 (organic cation transporter), member 1-like antisense
    • solute carrier family 22 (organic cation transporter), member 18 antisense
    • solute carrier family 22 member 1-like antisense protein
    • solute carrier family 22 member 18 antisense protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_169304.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC013791
      Related
      ENST00000625099.4

    2. NR_169305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC013791
      Related
      ENST00000455942.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      2887344..2903575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187585.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      119555..135790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      2976587..2992820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001302862.2: Suppressed sequence

      Description
      NM_001302862.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.

    2. NM_007105.4: Suppressed sequence

      Description
      NM_007105.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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