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    EIF3L eukaryotic translation initiation factor 3 subunit L [ Homo sapiens (human) ]

    Gene ID: 51386, updated on 27-Nov-2024

    Summary

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    Official Symbol
    EIF3Lprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Lprovided by HGNC
    Primary source
    HGNC:HGNC:18138
    See related
    Ensembl:ENSG00000100129 MIM:619197; AllianceGenome:HGNC:18138
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP
    Summary
    Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EIF3L in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37849419..37889407)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38311024..38351034)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38245426..38285414)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38244545-38245067 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245068-38245590 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38245591-38246112 Neighboring gene Sharpr-MPRA regulatory region 5684 Neighboring gene microRNA 658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38252750-38253250 Neighboring gene microRNA 659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38253251-38253751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38258557-38259056 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38276085-38276244 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38290604-38291248 Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38294770-38295536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38300995-38301810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38301811-38302626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38302627-38303442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38303443-38304256 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38306246-38307039 Neighboring gene MICAL like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38313076-38313576 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:38313949-38314111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314373-38314874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38314875-38315374 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329039-38329841 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38329842-38330643

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication. Morais ATs, et al. Virol J, 2013 Jun 22. PMID 23800076, Free PMC Article
    2. Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively. Herrmannová A, et al. Nucleic Acids Res, 2020 Feb 28. PMID 31863585, Free PMC Article
    3. The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3. Morris-Desbois C, et al. J Biol Chem, 2001 Dec 7. PMID 11590142
    4. Subunit architecture of multiprotein assemblies determined using restraints from gas-phase measurements. Pukala TL, et al. Structure, 2009 Sep 9. PMID 19748344
    5. Ubiquitin-specific protease 2a promotes hepatocellular carcinoma progression via deubiquitination and stabilization of RAB1A. Xiong B, et al. Cell Oncol (Dordr), 2021 Apr. PMID 33074477

    See all (188) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
      Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
    2. These results indicate an interaction of human eIF3L with yellow fever virus NS5 and that eIF3L overexpression facilitates translation, which has potential implications for virus replication.
      Title: The eukaryotic translation initiation factor 3 subunit L protein interacts with Flavivirus NS5 and may modulate yellow fever virus replication.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit L (EIF3L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit L (EIF3L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational termination-reinitiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit L
    Names
    eIEF associated protein HSPC021
    eukaryotic translation initiation factor 3 subunit 6-interacting protein
    eukaryotic translation initiation factor 3 subunit E-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242923.2 → NP_001229852.1  eukaryotic translation initiation factor 3 subunit L isoform 2

      See identical proteins and their annotated locations for NP_001229852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK302346, AL022311, CD638692, DA663575, Z97630
      Consensus CDS
      CCDS56230.1
      UniProtKB/TrEMBL
      B4DQF6
      Related
      ENSP00000371099.4, ENST00000381683.10
      Conserved Domains (1) summary
      pfam10255
      Location:146 → 502
      Paf67; RNA polymerase I-associated factor PAF67

    2. NM_001363785.2 → NP_001350714.1  eukaryotic translation initiation factor 3 subunit L isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL022311, BC029265, DA947257
      Consensus CDS
      CCDS87024.1
      UniProtKB/TrEMBL
      A0A024R1K4, B0QY90
      Related
      ENSP00000384634.1, ENST00000406934.5
      Conserved Domains (1) summary
      pfam10255
      Location:54 → 452
      Paf67; RNA polymerase I-associated factor PAF67

    3. NM_016091.4 → NP_057175.1  eukaryotic translation initiation factor 3 subunit L isoform 1

      See identical proteins and their annotated locations for NP_057175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL022311, BC029265, DA051005
      Consensus CDS
      CCDS13960.1
      UniProtKB/Swiss-Prot
      B2RDG6, B4DYB2, G8JLH4, Q53HQ1, Q53HT4, Q5QTR1, Q5TI15, Q6ICD2, Q9Y262
      UniProtKB/TrEMBL
      B4DQF6
      Related
      ENSP00000499067.1, ENST00000652021.1
      Conserved Domains (1) summary
      pfam10255
      Location:152 → 550
      Paf67; RNA polymerase I-associated factor PAF67

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      37849419..37889407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724260.5 → XP_006724323.2  eukaryotic translation initiation factor 3 subunit L isoform X1

    2. XM_047441389.1 → XP_047297345.1  eukaryotic translation initiation factor 3 subunit L isoform X2

      UniProtKB/TrEMBL
      A0A024R1K4, B0QY90

    3. XM_047441390.1 → XP_047297346.1  eukaryotic translation initiation factor 3 subunit L isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      38311024..38351034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325671.1 → XP_054181646.1  eukaryotic translation initiation factor 3 subunit L isoform X1

    2. XM_054325672.1 → XP_054181647.1  eukaryotic translation initiation factor 3 subunit L isoform X2

      UniProtKB/TrEMBL
      A0A024R1K4, B0QY90

    3. XM_054325673.1 → XP_054181648.1  eukaryotic translation initiation factor 3 subunit L isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y262.1 GenPept UniProtKB/Swiss-Prot:Q9Y262

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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