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    Zfp438 zinc finger protein 438 [ Mus musculus (house mouse) ]

    Gene ID: 240186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp438provided by MGI
    Official Full Name
    zinc finger protein 438provided by MGI
    Primary source
    MGI:MGI:2444919
    See related
    Ensembl:ENSMUSG00000050945 AllianceGenome:MGI:2444919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430031G09; 9430091M14Rik; B830013J05Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in early conceptus; gonad; limb; and ureter. Orthologous to human ZNF438 (zinc finger protein 438). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 12.1), bladder adult (RPKM 1.5) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp438 in Genome Data Viewer
    Location:
    18 A1; 18 3.02 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (5210027..5334826, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (5210027..5334826, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43692 Neighboring gene predicted gene, 53196 Neighboring gene STARR-seq mESC enhancer starr_43693 Neighboring gene predicted gene, 26682 Neighboring gene STARR-seq mESC enhancer starr_43694 Neighboring gene STARR-positive B cell enhancer mm9_chr18:5334784-5335085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:5347140-5347323 Neighboring gene predicted gene, 52372 Neighboring gene predicted gene, 34630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 438

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360447.1 → NP_001347376.1  zinc finger protein 438

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC111128, AC133945
      Consensus CDS
      CCDS37721.1
      UniProtKB/TrEMBL
      Q8BFX2, Q8BXJ4
      Related
      ENSMUSP00000156983.2, ENSMUST00000234241.2
      Conserved Domains (3) summary
      sd00017
      Location:495 → 515
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:521 → 543
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:507 → 532
      zf-H2C2_2; Zinc-finger double domain

    2. NM_178722.5 → NP_848837.3  zinc finger protein 438

      See identical proteins and their annotated locations for NP_848837.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK034745, AK046812
      Consensus CDS
      CCDS37721.1
      UniProtKB/TrEMBL
      Q8BFX2, Q8BXJ4
      Related
      ENSMUSP00000067049.6, ENSMUST00000063989.7
      Conserved Domains (3) summary
      sd00017
      Location:495 → 515
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:521 → 543
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:507 → 532
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      5210027..5334826 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161137.1 → XP_036017030.1  zinc finger protein 438 isoform X2

      UniProtKB/TrEMBL
      Q8BXJ4
      Conserved Domains (2) summary
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:456 → 478
      zf-C2H2; Zinc finger, C2H2 type

    2. XM_011246916.2 → XP_011245218.1  zinc finger protein 438 isoform X1

      See identical proteins and their annotated locations for XP_011245218.1

      UniProtKB/TrEMBL
      Q8BFX2, Q8BXJ4
      Conserved Domains (3) summary
      sd00017
      Location:495 → 515
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:521 → 543
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:507 → 532
      zf-H2C2_2; Zinc-finger double domain

    3. XM_036161136.1 → XP_036017029.1  zinc finger protein 438 isoform X2

      UniProtKB/TrEMBL
      Q8BXJ4
      Conserved Domains (2) summary
      sd00017
      Location:430 → 450
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:456 → 478
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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