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    Ermn ermin, ERM-like protein [ Mus musculus (house mouse) ]

    Gene ID: 77767, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ermnprovided by MGI
    Official Full Name
    ermin, ERM-like proteinprovided by MGI
    Primary source
    MGI:MGI:1925017
    See related
    Ensembl:ENSMUSG00000026830 AllianceGenome:MGI:1925017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ermin; mKIAA1189; A330104H05Rik
    Summary
    Enables actin filament binding activity. Acts upstream of or within several processes, including actin filament organization; morphogenesis of a branching structure; and regulation of cell shape. Located in several cellular components, including filopodium; glial cell projection; and main axon. Orthologous to human ERMN (ermin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 16.3), cortex adult (RPKM 9.4) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Ermn in Genome Data Viewer
    Location:
    2 C1.1; 2 32.99 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (57874920..57942962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (58045115..58052864, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial pseudogene Neighboring gene predicted gene, 25388 Neighboring gene STARR-seq mESC enhancer starr_04536 Neighboring gene STARR-seq mESC enhancer starr_04537 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57771733-57772033 Neighboring gene STARR-seq mESC enhancer starr_04538 Neighboring gene STARR-seq mESC enhancer starr_04539 Neighboring gene STARR-positive B cell enhancer mm9_chr2:57882224-57882524 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_04540 Neighboring gene STARR-positive B cell enhancer ABC_E3374 Neighboring gene STARR-positive B cell enhancer ABC_E2036 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1589 Neighboring gene STARR-positive B cell enhancer ABC_E3375 Neighboring gene STARR-positive B cell enhancer ABC_E5917 Neighboring gene STARR-positive B cell enhancer ABC_E5918 Neighboring gene STARR-positive B cell enhancer ABC_E7817 Neighboring gene STARR-positive B cell enhancer ABC_E5919 Neighboring gene cytohesin 1 interacting protein Neighboring gene predicted gene 13546

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ermin is a p116(RIP) -interacting protein promoting oligodendroglial differentiation and myelin maintenance. Wang S, et al. Glia, 2020 Nov. PMID 32530539
    2. Juxtanodin in retinal pigment epithelial cells: Expression and biological activities in regulating cell morphology and actin cytoskeleton organization. Liang F, et al. J Comp Neurol, 2018 Feb 1. PMID 28815590
    3. Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology. Brockschnieder D, et al. J Neurosci, 2006 Jan 18. PMID 16421295, Free PMC Article
    4. Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. He D, et al. Nat Neurosci, 2016 May. PMID 26928066, Free PMC Article
    5. Profiling, Bioinformatic, and Functional Data on the Developing Olfactory/GnRH System Reveal Cellular and Molecular Pathways Essential for This Process and Potentially Relevant for the Kallmann Syndrome. Garaffo G, et al. Front Endocrinol (Lausanne), 2013. PMID 24427155, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonstrated that the Juxtanodin expression in rat retinal pigment epithelial cells, and Juxtanodin functional roles in regulating actin cytoskeleton architecture and morphology.
      Title: Juxtanodin in retinal pigment epithelial cells: Expression and biological activities in regulating cell morphology and actin cytoskeleton organization.
    2. plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis
      Title: Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1189, MGC107206

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in morphogenesis of a branching structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within morphogenesis of a branching structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell projection organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell projection organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in internode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in internode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in internode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in paranode region of axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in paranode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ermin
    Names
    JN
    juxtanodin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029972.4 → NP_084248.2  ermin

      See identical proteins and their annotated locations for NP_084248.2

      Status: VALIDATED

      Source sequence(s)
      AL928564
      Consensus CDS
      CCDS16047.1
      UniProtKB/Swiss-Prot
      Q3UVY3, Q5DTZ8, Q5EBJ4, Q8C5L8, Q9CTR3
      Related
      ENSMUSP00000088458.6, ENSMUST00000090940.6
      Conserved Domains (1) summary
      pfam00769
      Location:261 → 278
      ERM; Ezrin/radixin/moesin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      57874920..57942962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162717.1 → XP_036018610.1  ermin isoform X1

    2. XM_036162719.1 → XP_036018612.1  ermin isoform X2

    3. XM_036162718.1 → XP_036018611.1  ermin isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EBJ4.1 GenPept UniProtKB/Swiss-Prot:Q5EBJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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