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    Klhl18 kelch-like 18 [ Mus musculus (house mouse) ]

    Gene ID: 270201, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhl18provided by MGI
    Official Full Name
    kelch-like 18provided by MGI
    Primary source
    MGI:MGI:2143315
    See related
    Ensembl:ENSMUSG00000054792 AllianceGenome:MGI:2143315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A930041K15
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in nervous system and retina nuclear layer. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 10.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl18 in Genome Data Viewer
    Location:
    9 F2; 9 59.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110254994..110305768, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110425926..110476737, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene STARR-positive B cell enhancer ABC_E6807 Neighboring gene neutrophilic granule protein Neighboring gene STARR-positive B cell enhancer ABC_E8318 Neighboring gene kinesin family member 9 Neighboring gene STARR-seq mESC enhancer starr_25264 Neighboring gene SET domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss. Ingham NJ, et al. PLoS One, 2021. PMID 34597341, Free PMC Article
    2. Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. Lewis MA, et al. BMC Biol, 2022 Mar 17. PMID 35296311, Free PMC Article
    3. Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. Chaya T, et al. EMBO J, 2019 Dec 2. PMID 31696965, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss.
      Title: Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss.
    2. suggest that Cul3-Klhl18 modulates rod Talpha translocation during light/dark adaptation through Unc119 ubiquitination
      Title: Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36415

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360306.1 → NP_001347235.1  kelch-like protein 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132103, AC160104, BC065167
      Consensus CDS
      CCDS90672.1
      UniProtKB/TrEMBL
      A0A0G2JGN5
      Related
      ENSMUSP00000143634.2, ENSMUST00000198164.5
      Conserved Domains (4) summary
      PHA03098
      Location:34 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:331 → 374
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    2. NM_177771.5 → NP_808439.2  kelch-like protein 18 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132103, BC065167, BY195998, BY248410, CB247282, CF739377, CK619719
      Consensus CDS
      CCDS23567.1
      UniProtKB/Swiss-Prot
      E9Q4F2
      Related
      ENSMUSP00000069674.7, ENSMUST00000068025.13
      Conserved Domains (4) summary
      PHA03098
      Location:34 → 552
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:326 → 369
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 241
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110254994..110305768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244406.2 → XP_030100266.1  kelch-like protein 18 isoform X2

      Conserved Domains (3) summary
      PHA03098
      Location:3 → 440
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:214 → 257
      Kelch; KELCH repeat [structural motif]
      cd18457
      Location:23 → 129
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    2. XM_030244405.2 → XP_030100265.1  kelch-like protein 18 isoform X1

      Conserved Domains (3) summary
      PHA03098
      Location:3 → 445
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:219 → 262
      Kelch; KELCH repeat [structural motif]
      cd18457
      Location:23 → 129
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

    3. XM_017313405.3 → XP_017168894.1  kelch-like protein 18 isoform X3

      Conserved Domains (5) summary
      smart00612
      Location:318 → 370
      Kelch; Kelch domain
      sd00038
      Location:311 → 356
      Kelch; KELCH repeat [structural motif]
      cd18247
      Location:19 → 134
      BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
      cd18457
      Location:135 → 270
      BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
      pfam01344
      Location:359 → 404
      Kelch_1; Kelch motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q4F2.1 GenPept UniProtKB/Swiss-Prot:E9Q4F2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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