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    Lta4h leukotriene A4 hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 16993, updated on 13-Jan-2025

    Summary

    Official Symbol
    Lta4hprovided by MGI
    Official Full Name
    leukotriene A4 hydrolaseprovided by MGI
    Primary source
    MGI:MGI:96836
    See related
    Ensembl:ENSMUSG00000015889 AllianceGenome:MGI:96836
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 63.2), duodenum adult (RPKM 45.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Lta4h in Genome Data Viewer
    Location:
    10 C2; 10 48.42 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (93289258..93320758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (93453396..93484896)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 7688 Neighboring gene nuclear encoded tRNA aspartic acid 8 (anticodon GTC) Neighboring gene predicted gene, 57556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:92930719-92930828 Neighboring gene histidine ammonia lyase Neighboring gene amidohydrolase domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity  
    enables aminopeptidase activity  
    enables aminopeptidase activity  
    enables epoxide hydrolase activity  
    enables epoxide hydrolase activity  
    enables epoxide hydrolase activity  
    enables leukotriene-A4 hydrolase activity  
    enables leukotriene-A4 hydrolase activity  
    enables leukotriene-A4 hydrolase activity  
    enables metalloaminopeptidase activity  
    enables metalloaminopeptidase activity  
    enables protein binding PubMed 
    enables tripeptide aminopeptidase activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in leukotriene biosynthetic process  
    involved_in leukotriene biosynthetic process  
    involved_in leukotriene biosynthetic process  
    involved_in leukotriene metabolic process  
    involved_in peptide catabolic process  
    involved_in peptide catabolic process  
    involved_in peptide catabolic process  
    involved_in protein metabolic process  
    involved_in proteolysis  
    involved_in response to peptide hormone  
    involved_in response to zinc ion  
    involved_in type I pneumocyte differentiation  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    leukotriene A-4 hydrolase
    Names
    LTA-4 hydrolase
    LTA4 hydrodase
    tripeptide aminopeptidase LTA4H
    NP_001300826.1
    NP_032543.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313897.1NP_001300826.1  leukotriene A-4 hydrolase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate coding exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK134931, BF018223, BG807829, BY793553
      UniProtKB/Swiss-Prot
      P24527
      Conserved Domains (3) summary
      cd09599
      Location:6450
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      pfam01433
      Location:21387
      Peptidase_M1; Peptidase family M1
      pfam09127
      Location:468521
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    2. NM_008517.2NP_032543.2  leukotriene A-4 hydrolase isoform 1

      See identical proteins and their annotated locations for NP_032543.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK134931, AW121450, BY458968, BY793553
      Consensus CDS
      CCDS24125.1
      UniProtKB/Swiss-Prot
      P24527, Q3UY71, Q8VDR8
      Related
      ENSMUSP00000016033.8, ENSMUST00000016033.9
      Conserved Domains (3) summary
      cd09599
      Location:6450
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:6608
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:468607
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      93289258..93320758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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