Cmklr2 chemerin chemokine-like receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmklr2provided by MGI
Official Full Name: chemerin chemokine-like receptor 2provided by MGI
Primary source: MGI:MGI:2385324
See related: Ensembl:ENSMUSG00000046856 AllianceGenome:MGI:2385324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr1
Summary: Predicted to enable several functions, including adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and neuropeptide binding activity. Involved in glucose homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in neuron projection and plasma membrane. Is expressed in several structures, including brain; early conceptus; exocrine gland; genitourinary system; and hemolymphoid system gland. Orthologous to human CMKLR2 (chemerin chemokine-like receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in placenta adult (RPKM 8.1), mammary gland adult (RPKM 1.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 32.31 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (63221737..63253714, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (63182571..63223278, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with beta-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking.
Title: The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking.
An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis.
Title: An Antagonistic Peptide of Gpr1 Ameliorates LPS-Induced Depression through the Hypothalamic-Pituitary-Ovarian Axis.
GPR1 plays a role in regulating choriocarcinoma progression.
Title: Role of G protein-coupled receptor 1 in choriocarcinoma progression.
In pregnant mice, GPR1 knockdown exacerbated glucose intolerance, disrupted lipid metabolism, and decreased beta-cell proliferation and insulin levels.
Title: Impact of GPR1 signaling on maternal high-fat feeding and placenta metabolism in mice.
Gpr1 deficiency leads to the improvement of steroid synthesis in mice hyperandrogenized with DHEA, indicating that GPR1 may be a therapeutic target for DHEA-induced hyperandrogenism.
Title: Deficiency of Gpr1 improves steroid hormone abnormality in hyperandrogenized mice.
This study provides further support the hypothesis that a functional chemerin system is required for the maintenance of healthy glucose homeostasis during obesity in mice lacking the active chemerin receptor GPR1.
Title: Gpr1 is an active chemerin receptor influencing glucose homeostasis in obese mice.
a maternal germline differentially methylated region (DMR) at the mouse Gpr1/Zdbf2 (DBF-type zinc finger-containing protein 2) locus, which controls the paternal-specific expression of long isoforms of Zdbf2 (Liz) in the early embryo
Title: The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals.
Results identified a novel, paternally expressed, long intergenic non-coding Zdbf2 variant (Zdbf2linc) transcribed from maternally methylated Gpr1 during early embryogenesis in the mouse.
Title: Imprinted DNA methylation reprogramming during early mouse embryogenesis at the Gpr1-Zdbf2 locus is linked to long cis-intergenic transcription.
Identification of differentially methylated regions within the Gpr1-Zdbf2 imprinted domain.
Title: A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:546800

Gpr1 (e-PCR), detects polymorphism
- UniSTS:546800

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adipokinetic hormone binding	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chemerin-like receptor 2

Names: G protein-coupled receptor 1; chemokine-like receptor 2; probable G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357045.2 → NP_001343974.1 chemerin-like receptor 2

Status: VALIDATED

Source sequence(s)

AL645950

Consensus CDS

CCDS14998.1

UniProtKB/Swiss-Prot

Q8K087

Conserved Domains (1) summary

cd15119
Location:39 → 313

7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_146250.3 → NP_666362.1 chemerin-like receptor 2

See identical proteins and their annotated locations for NP_666362.1

Status: VALIDATED

Source sequence(s)

AL645950

Consensus CDS

CCDS14998.1

UniProtKB/Swiss-Prot

Q8K087

Related

ENSMUSP00000051417.8, ENSMUST00000050536.14

Conserved Domains (1) summary

cd15119
Location:39 → 313

7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

63221737..63253714 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006495981.4 → XP_006496044.1 chemerin-like receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006496044.1

UniProtKB/Swiss-Prot

Q8K087

Conserved Domains (1) summary

cd15119
Location:39 → 313

7tmA_GPR1; G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors