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    Tymp thymidine phosphorylase [ Mus musculus (house mouse) ]

    Gene ID: 72962, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tympprovided by MGI
    Official Full Name
    thymidine phosphorylaseprovided by MGI
    Primary source
    MGI:MGI:1920212
    See related
    Ensembl:ENSMUSG00000022615 AllianceGenome:MGI:1920212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TP; Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
    Summary
    Enables thymidine phosphorylase activity. Involved in dTMP catabolic process. Predicted to be active in cytosol. Is expressed in alimentary system; axial skeleton; central nervous system; hindlimb; and retina. Used to study mitochondrial DNA depletion syndrome 1. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; mitochondrial DNA depletion syndrome 1; mitochondrial encephalomyopathy; pancreatic cancer; and transitional cell carcinoma. Orthologous to human TYMP (thymidine phosphorylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 180.1), liver adult (RPKM 127.9) and 17 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tymp in Genome Data Viewer
    Location:
    15 E3; 15 44.86 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (89255834..89261282, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (89371631..89377036, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39462 Neighboring gene myo-inositol oxygenase Neighboring gene STARR-positive B cell enhancer ABC_E7405 Neighboring gene STARR-positive B cell enhancer ABC_E3152 Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene STARR-seq mESC enhancer starr_39464 Neighboring gene SCO2 cytochrome c oxidase assembly protein Neighboring gene ciliary microtubule associated protein 1B Neighboring gene kelch domain containing 7B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1,4-alpha-oligoglucan phosphorylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thymidine phosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables thymidine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    thymidine phosphorylase
    Names
    endothelial cell growth factor 1 (platelet-derived)
    gliostatin
    platelet derived growth factor, endothelial cell
    tdRPase
    NP_612175.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138302.3NP_612175.1  thymidine phosphorylase

      See identical proteins and their annotated locations for NP_612175.1

      Status: VALIDATED

      Source sequence(s)
      AC113976
      Consensus CDS
      CCDS27747.1
      UniProtKB/Swiss-Prot
      Q99N42
      Related
      ENSMUSP00000023285.5, ENSMUST00000023285.5
      Conserved Domains (4) summary
      PRK05820
      Location:23456
      deoA; thymidine phosphorylase; Reviewed
      smart00941
      Location:374448
      PYNP_C; Pyrimidine nucleoside phosphorylase C-terminal domain
      pfam00591
      Location:96326
      Glycos_transf_3; Glycosyl transferase family, a/b domain
      pfam02885
      Location:2484
      Glycos_trans_3N; Glycosyl transferase family, helical bundle domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      89255834..89261282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028405.1: Suppressed sequence

      Description
      NM_028405.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.