Slc35d3 solute carrier family 35, member D3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc35d3provided by MGI
Official Full Name: solute carrier family 35, member D3provided by MGI
Primary source: MGI:MGI:1923407
See related: Ensembl:ENSMUSG00000050473 AllianceGenome:MGI:1923407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Frcl1; 6230421J19Rik
Summary: Enables UDP-glucose transmembrane transporter activity and protein-macromolecule adaptor activity. Involved in UDP-glucose transmembrane transport; platelet dense granule organization; and positive regulation of autophagy. Acts upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Located in early endosome and endoplasmic reticulum. Is active in early endosome membrane. Is expressed in midbrain mantle layer and thymus primordium. Orthologous to human SLC35D3 (solute carrier family 35 member D3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in adrenal adult (RPKM 13.5), frontal lobe adult (RPKM 1.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 9.12 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (19723662..19728195, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (19847917..19856634, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling.
Title: SLC35D3 promotes white adipose tissue browning to ameliorate obesity by NOTCH signaling.
that SLC35D3 enhanced the formation of the BECN1-ATG14-PIK3C3 complex to induce autophagy
Title: SLC35D3 increases autophagic activity in midbrain dopaminergic neurons by enhancing BECN1-ATG14-PIK3C3 complex formation.
SLC35D3 is depleted in platelets from 2 of 3 Hermansky-Pudlak syndrome models and, when expressed ectopically in melanocytes, SLC35D3 localizes to melanosomes in a manner requiring a HPS-associated protein complex
Title: SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.
Slc35d3 specifically regulates the contents of platelet-dense granules. Unlike HPS or CHS genes, it has no apparent effect on other lysosome-related organelles such as melanosomes or lysosomes
Title: The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation

General gene information

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Markers

Slc35d3 (e-PCR), detects polymorphism
- UniSTS:547092

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables UDP-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables UDP-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in UDP-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in UDP-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet dense granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein exit from endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein exit from endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: solute carrier family 35 member D3

Names: frc, fringe-like 1; fringe connection-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029529.3 → NP_083805.1 solute carrier family 35 member D3

See identical proteins and their annotated locations for NP_083805.1

Status: VALIDATED

Source sequence(s)

AC171277

Consensus CDS

CCDS23719.1

UniProtKB/Swiss-Prot

Q8BGF8, Q9CXD4

UniProtKB/TrEMBL

B9EI54

Related

ENSMUSP00000060589.5, ENSMUST00000059805.6

Conserved Domains (1) summary

COG5070
Location:30 → 308

VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

19723662..19728195 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512916.5 → XP_006512979.1 solute carrier family 35 member D3 isoform X1

Conserved Domains (1) summary

pfam08449
Location:19 → 152

UAA; UAA transporter family