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    TOMM34 translocase of outer mitochondrial membrane 34 [ Homo sapiens (human) ]

    Gene ID: 10953, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TOMM34provided by HGNC
    Official Full Name
    translocase of outer mitochondrial membrane 34provided by HGNC
    Primary source
    HGNC:HGNC:15746
    See related
    Ensembl:ENSG00000025772 MIM:616049; AllianceGenome:HGNC:15746
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOM34; URCC3; HTOM34P
    Summary
    The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 58.9), adrenal (RPKM 15.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TOMM34 in Genome Data Viewer
    Location:
    20q13.12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (44942130..44960397, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (46677999..46696286, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43570771..43589038, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:43514076-43514692 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545042-43545542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:43545543-43546043 Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene uncharacterized LOC124904912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17943 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12953 Neighboring gene STK4 divergent transcript Neighboring gene serine/threonine kinase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12954

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities. Durech M, et al. Mol Cell Proteomics, 2016 May. PMID 26944342, Free PMC Article
    2. High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma. Cai M, et al. Pathol Oncol Res, 2021. PMID 34257607, Free PMC Article
    3. Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target. Shimokawa T, et al. Int J Oncol, 2006 Aug. PMID 16820880
    4. TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome. Aleskandarany MA, et al. Breast Cancer Res Treat, 2012 Nov. PMID 23053644
    5. The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors. Trcka F, et al. J Biol Chem, 2020 Jul 3. PMID 32371396, Free PMC Article

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of TOMM34 on NF-kappaB activation-related hyperinflammation in severely ill patients with COVID-19 and influenza.
      Title: Role of TOMM34 on NF-κB activation-related hyperinflammation in severely ill patients with COVID-19 and influenza.
    2. TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
      Title: TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
    3. High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.
      Title: High Expression of Tomm34 and Its Correlations With Clinicopathology in Oral Squamous Cell Carcinoma.
    4. Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.
      Title: Expression of TOMM34 and Its Clinicopathological Correlations in Urothelial Carcinoma of the Bladder.
    5. The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
      Title: The interaction of the mitochondrial protein importer TOMM34 with HSP70 is regulated by TOMM34 phosphorylation and binding to 14-3-3 adaptors.
    6. Translocase of outer mitochondrial membrane 34 (Tomm34) is commonly expressed at high levels in epithelial ovarian cancers, except for the clear cell and mucinous subtypes. The expression of Tomm34 is positively correlated with FIGO stage. Tomm34 levels also indicates poor prognosis and progression for patients with mutant p53.
      Title: Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.
    7. TOM34 and its partner HSP90AA1 might be used as a potential biomarker for monitoring HCV-induced hepatocellular carcinoma progression in the Egyptian population. Future large-scale validation studies are warranted.
      Title: Overexpression of heat shock protein HSP90AA1 and translocase of the outer mitochondrial membrane TOM34 in HCV-induced hepatocellular carcinoma: A pilot study.
    8. Data show that Tomm34 extensively interacts with the C-terminal structures of Hsp70 selectively in its ATP-bound state and that this interaction is strongly entropically driven.
      Title: Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities.
    9. These results suggest that Tomm34 represents a novel scaffolding co-chaperone of Hsp70 and Hsp90, which may facilitate Hsp70/Hsp90 cooperation during protein folding
      Title: The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex.
    10. TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
      Title: TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein targeting to mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM34
    Names
    outer mitochondrial membrane translocase (34kD)
    translocase of outer membrane 34 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006809.5 → NP_006800.2  mitochondrial import receptor subunit TOM34

      See identical proteins and their annotated locations for NP_006800.2

      Status: REVIEWED

      Source sequence(s)
      BC001763, BC006573, BC007423, BI560064
      Consensus CDS
      CCDS13340.1
      UniProtKB/Swiss-Prot
      Q15785, Q53GH9, Q6IBN7, Q9NTZ3
      UniProtKB/TrEMBL
      B4DXU3
      Related
      ENSP00000361900.3, ENST00000372813.4
      Conserved Domains (2) summary
      sd00006
      Location:193 → 221
      TPR; TPR repeat [structural motif]
      cl26005
      Location:12 → 294
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      44942130..44960397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528501.2 → XP_011526803.1  mitochondrial import receptor subunit TOM34 isoform X1

      UniProtKB/TrEMBL
      B4DXU3
      Conserved Domains (3) summary
      sd00006
      Location:167 → 195
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:203 → 234
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:166 → 231
      TPR_11; TPR repeat

    2. XM_017027600.3 → XP_016883089.1  mitochondrial import receptor subunit TOM34 isoform X2

      Conserved Domains (3) summary
      smart00028
      Location:88 → 117
      TPR; Tetratricopeptide repeats
      sd00006
      Location:9 → 37
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:10 → 82
      TPR_11; TPR repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      46677999..46696286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322868.1 → XP_054178843.1  mitochondrial import receptor subunit TOM34 isoform X1

      UniProtKB/TrEMBL
      B4DXU3

    2. XM_054322869.1 → XP_054178844.1  mitochondrial import receptor subunit TOM34 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15785.2 GenPept UniProtKB/Swiss-Prot:Q15785

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