GPR3 G protein-coupled receptor 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR3provided by HGNC
Official Full Name: G protein-coupled receptor 3provided by HGNC
Primary source: HGNC:HGNC:4484
See related: Ensembl:ENSG00000181773 MIM:600241; AllianceGenome:HGNC:4484
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACCA
Summary: This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
Expression: Broad expression in brain (RPKM 2.0), thyroid (RPKM 0.6) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (27392622..27395814)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (27233946..27237138)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (27719126..27722318)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rare variants in GPR3 in POI patients: a case series with review of literature.
Title: Rare variants in GPR3 in POI patients: a case series with review of literature.
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Title: Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human beta cell proliferation.
Title: Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.
Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.
Title: Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.
these results suggest an important role of the allosteric sodium binding site for GPR3 activity and open a possible avenue for the modulation of Abeta production in the Alzheimer's Disease.
Title: Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.
Results demonstrate that GPR3 signals at the plasma membrane and can be silenced by GRK2/beta-arrestin overexpression. These results also strongly implicate the serine and/or threonine residues in the third intracellular loop in the regulation of GPR3 activity.
Title: Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.
Gpr3 stimulates Abeta production via interactions with APP and beta-arrestin2.
Title: Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2.
GPR3 is a key factor in the regulation of the nervous system and follicle development.[review]
Title: [G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development].
GPR3 is expressed in the ovary and testes, and is necessary for the regulation of meiosis in mouse.
Title: The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.
Mutations in GPR3 are not a common cause of premature ovarian failure in Chinese women.
Title: GPR3 may not be a potential candidate gene for premature ovarian failure.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70930 (e-PCR)
- UniSTS:28483

GPR3_2356 (e-PCR)
- UniSTS:280723

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cAMP-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor 3

Names: ACCA orphan receptor; adenylate cyclase constitutive activator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005281.4 → NP_005272.1 G-protein coupled receptor 3

See identical proteins and their annotated locations for NP_005272.1

Status: REVIEWED

Source sequence(s)

FO393419

Consensus CDS

CCDS303.1

UniProtKB/Swiss-Prot

A8K570, P46089

UniProtKB/TrEMBL

F1DAM5

Related

ENSP00000363136.3, ENST00000374024.4

Conserved Domains (2) summary

cd14964
Location:43 → 67

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:41 → 308

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily