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    ARMH1 armadillo like helical domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 339541, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ARMH1provided by HGNC
    Official Full Name
    armadillo like helical domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:34345
    See related
    Ensembl:ENSG00000198520 AllianceGenome:HGNC:34345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p40; C1orf228; NCRNA00082
    Expression
    Biased expression in bone marrow (RPKM 8.3), testis (RPKM 3.2) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARMH1 in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (44674714..44725591)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (44545660..44596534)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45140386..45191263)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ring finger protein 220 Neighboring gene uncharacterized LOC107984950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45115956-45116537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 942 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:45139597-45140098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 814 Neighboring gene transmembrane protein 53 Neighboring gene uncharacterized LOC105378690 Neighboring gene small nucleolar RNA, C/D box 145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 815 Neighboring gene Sharpr-MPRA regulatory region 12667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 816 Neighboring gene Sharpr-MPRA regulatory region 12642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:45200330-45200889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 943 Neighboring gene RNA, U5F small nuclear 1 Neighboring gene RNA, U5D small nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 944 Neighboring gene kinesin family member 2C Neighboring gene small nucleolar RNA, C/D box 160

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors. Feng X, et al. Sci Adv, 2022 May 13. PMID 35559673, Free PMC Article
    2. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
    3. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
    4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC33556

    General protein information

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    Preferred Names
    armadillo-like helical domain containing protein 1
    Names
    uncharacterized protein C1orf228

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145636.2 → NP_001139108.1  armadillo-like helical domain containing protein 1

      See identical proteins and their annotated locations for NP_001139108.1

      Status: VALIDATED

      Source sequence(s)
      AL122004, AY254217, BC026115, BX112141
      Consensus CDS
      CCDS53311.1
      UniProtKB/Swiss-Prot
      A1KXE5, Q6PIY5
      Related
      ENSP00000440524.1, ENST00000535358.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      44674714..44725591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541340.2 → XP_011539642.1  armadillo-like helical domain containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011539642.1

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    2. XM_006710603.3 → XP_006710666.1  armadillo-like helical domain containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006710666.1

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    3. XM_011541345.2 → XP_011539647.1  armadillo-like helical domain containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 255
      DUF5578; Family of unknown function (DUF5578)

    4. XM_006710604.3 → XP_006710667.1  armadillo-like helical domain containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006710667.1

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    5. XM_011541343.2 → XP_011539645.1  armadillo-like helical domain containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011539645.1

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    6. XM_047419337.1 → XP_047275293.1  armadillo-like helical domain containing protein 1 isoform X1

    7. XM_047419352.1 → XP_047275308.1  armadillo-like helical domain containing protein 1 isoform X3

    8. XM_011541341.2 → XP_011539643.1  armadillo-like helical domain containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011539643.1

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    9. XM_047419358.1 → XP_047275314.1  armadillo-like helical domain containing protein 1 isoform X5

    10. XM_017001142.2 → XP_016856631.1  armadillo-like helical domain containing protein 1 isoform X6

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    11. XM_017001143.2 → XP_016856632.1  armadillo-like helical domain containing protein 1 isoform X9

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    12. XM_011541349.3 → XP_011539651.1  armadillo-like helical domain containing protein 1 isoform X8

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 198
      DUF5578; Family of unknown function (DUF5578)

    13. XM_047419380.1 → XP_047275336.1  armadillo-like helical domain containing protein 1 isoform X18

    14. XM_047419371.1 → XP_047275327.1  armadillo-like helical domain containing protein 1 isoform X14

    15. XM_047419362.1 → XP_047275318.1  armadillo-like helical domain containing protein 1 isoform X7

    16. XM_047419353.1 → XP_047275309.1  armadillo-like helical domain containing protein 1 isoform X4

    17. XM_047419367.1 → XP_047275323.1  armadillo-like helical domain containing protein 1 isoform X10

    18. XM_047419369.1 → XP_047275325.1  armadillo-like helical domain containing protein 1 isoform X11

    19. XM_047419370.1 → XP_047275326.1  armadillo-like helical domain containing protein 1 isoform X13

    20. XM_017001144.2 → XP_016856633.1  armadillo-like helical domain containing protein 1 isoform X12

      Conserved Domains (1) summary
      pfam17741
      Location:1 → 268
      DUF5578; Family of unknown function (DUF5578)

    21. XM_017001146.3 → XP_016856635.1  armadillo-like helical domain containing protein 1 isoform X16

      UniProtKB/TrEMBL
      C9JCY2
      Related
      ENSP00000420664.1, ENST00000441519.5
      Conserved Domains (1) summary
      pfam17741
      Location:1 → 242
      DUF5578; Family of unknown function (DUF5578)

    22. XM_017001147.2 → XP_016856636.1  armadillo-like helical domain containing protein 1 isoform X17

      UniProtKB/TrEMBL
      C9JCY2
      Related
      ENSP00000417998.1, ENST00000445071.5
      Conserved Domains (1) summary
      pfam17741
      Location:1 → 241
      DUF5578; Family of unknown function (DUF5578)

    23. XM_017001145.2 → XP_016856634.1  armadillo-like helical domain containing protein 1 isoform X15

      UniProtKB/TrEMBL
      C9JCY2
      Conserved Domains (1) summary
      pfam17741
      Location:1 → 242
      DUF5578; Family of unknown function (DUF5578)

    RNA

    1. XR_007059336.1 RNA Sequence

    2. XR_001737140.2 RNA Sequence

      Related
      ENST00000357508.5

    3. XR_001737141.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      44545660..44596534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336284.1 → XP_054192259.1  armadillo-like helical domain containing protein 1 isoform X1

    2. XM_054336283.1 → XP_054192258.1  armadillo-like helical domain containing protein 1 isoform X1

    3. XM_054336286.1 → XP_054192261.1  armadillo-like helical domain containing protein 1 isoform X2

    4. XM_054336285.1 → XP_054192260.1  armadillo-like helical domain containing protein 1 isoform X1

    5. XM_054336281.1 → XP_054192256.1  armadillo-like helical domain containing protein 1 isoform X1

    6. XM_054336282.1 → XP_054192257.1  armadillo-like helical domain containing protein 1 isoform X1

    7. XM_054336287.1 → XP_054192262.1  armadillo-like helical domain containing protein 1 isoform X3

    8. XM_054336280.1 → XP_054192255.1  armadillo-like helical domain containing protein 1 isoform X1

    9. XM_054336289.1 → XP_054192264.1  armadillo-like helical domain containing protein 1 isoform X5

    10. XM_054336290.1 → XP_054192265.1  armadillo-like helical domain containing protein 1 isoform X6

    11. XM_054336293.1 → XP_054192268.1  armadillo-like helical domain containing protein 1 isoform X9

    12. XM_054336292.1 → XP_054192267.1  armadillo-like helical domain containing protein 1 isoform X8

    13. XM_054336302.1 → XP_054192277.1  armadillo-like helical domain containing protein 1 isoform X18

    14. XM_054336298.1 → XP_054192273.1  armadillo-like helical domain containing protein 1 isoform X14

    15. XM_054336291.1 → XP_054192266.1  armadillo-like helical domain containing protein 1 isoform X7

    16. XM_054336288.1 → XP_054192263.1  armadillo-like helical domain containing protein 1 isoform X4

    17. XM_054336294.1 → XP_054192269.1  armadillo-like helical domain containing protein 1 isoform X10

    18. XM_054336295.1 → XP_054192270.1  armadillo-like helical domain containing protein 1 isoform X11

    19. XM_054336297.1 → XP_054192272.1  armadillo-like helical domain containing protein 1 isoform X13

    20. XM_054336296.1 → XP_054192271.1  armadillo-like helical domain containing protein 1 isoform X12

    21. XM_054336300.1 → XP_054192275.1  armadillo-like helical domain containing protein 1 isoform X16

    22. XM_054336301.1 → XP_054192276.1  armadillo-like helical domain containing protein 1 isoform X17

    23. XM_054336299.1 → XP_054192274.1  armadillo-like helical domain containing protein 1 isoform X15

    RNA

    1. XR_008486019.1 RNA Sequence

    2. XR_008486017.1 RNA Sequence

    3. XR_008486018.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004307.2: Suppressed sequence

      Description
      NM_001004307.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PIY5.2 GenPept UniProtKB/Swiss-Prot:Q6PIY5

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