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    Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 22273, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Uqcrc1provided by MGI
    Official Full Name
    ubiquinol-cytochrome c reductase core protein 1provided by MGI
    Primary source
    MGI:MGI:107876
    See related
    Ensembl:ENSMUSG00000025651 AllianceGenome:MGI:107876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110032G10Rik
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 872.4), duodenum adult (RPKM 565.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uqcrc1 in Genome Data Viewer
    Location:
    9 F2; 9 59.63 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108765716..108778709)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108936648..108949641)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5104 Neighboring gene solute carrier family 26, member 6 Neighboring gene transmembrane protein 89 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:108838602-108838711 Neighboring gene collagen, type VII, alpha 1 Neighboring gene microRNA 711 Neighboring gene urocortin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Critical role of UQCRC1 in embryo survival, brain ischemic tolerance and normal cognition in mice. Shan W, et al. Cell Mol Life Sci, 2019 Apr. PMID 30666338, Free PMC Article
    2. Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer. Wang Q, et al. Theranostics, 2020. PMID 32089737, Free PMC Article
    3. Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise. Yi T, et al. Exp Biol Med (Maywood), 2022 Jan. PMID 34648372, Free PMC Article
    4. Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Vrbacký M, et al. Hum Mol Genet, 2016 Nov 1. PMID 28173120
    5. Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes. Milenkovic D, et al. Cell Metab, 2023 Oct 3. PMID 37633273

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
      Title: Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
    2. Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
      Title: Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
    3. UQCRC1 is critical for the development and survival of embryos. UQCRC1 is also important for the proper function of the complex III, which may affect the brain ischemic tolerance and normal learning and memory.
      Title: Critical role of UQCRC1 in embryo survival, brain ischemic tolerance and normal cognition in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC97899

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial electron transport, ubiquinol to cytochrome c IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex III assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to alkaloid IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    part_of respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex III ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b-c1 complex subunit 1, mitochondrial
    Names
    complex III subunit 1
    core protein I
    ubiquinol-cytochrome-c reductase complex core protein 1
    NP_079683.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025407.2 → NP_079683.2  cytochrome b-c1 complex subunit 1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_079683.2

      Status: VALIDATED

      Source sequence(s)
      AI462428, AK010553, BB649589, BY260300
      Consensus CDS
      CCDS23540.1
      UniProtKB/Swiss-Prot
      Q3TV75, Q9CWL6, Q9CZ13
      UniProtKB/TrEMBL
      Q3TIC8
      Related
      ENSMUSP00000026743.9, ENSMUST00000026743.14
      Conserved Domains (3) summary
      COG0612
      Location:46 → 469
      PqqL; Predicted Zn-dependent peptidase [General function prediction only]
      pfam00675
      Location:58 → 205
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:210 → 395
      Peptidase_M16_C; Peptidase M16 inactive domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108765716..108778709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZ13.2 GenPept UniProtKB/Swiss-Prot:Q9CZ13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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