Zbtb11 zinc finger and BTB domain containing 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zbtb11provided by MGI
Official Full Name: zinc finger and BTB domain containing 11provided by MGI
Primary source: MGI:MGI:2443876
See related: Ensembl:ENSMUSG00000022601 AllianceGenome:MGI:2443876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZNF-U69274; 9230110G02Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Is expressed in central nervous system; genitourinary system; and inner ear. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 69. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 7.2), cerebellum adult (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.1; 16 33.74 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (55791820..55829276)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (55971437..56008913)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification.
Title: Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification.
The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.
Title: The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173026.2 → NP_766614.2 zinc finger and BTB domain-containing protein 11

See identical proteins and their annotated locations for NP_766614.2

Status: VALIDATED

Source sequence(s)

AC171202

Consensus CDS

CCDS49874.1

UniProtKB/Swiss-Prot

G5E8B9, Q8BZQ5

Related

ENSMUSP00000056923.8, ENSMUST00000050248.9

Conserved Domains (6) summary

COG5048
Location:664 → 837

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:678 → 698

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18202
Location:195 → 312

BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)

pfam13465
Location:897 → 920

zf-H2C2_2; Zinc-finger double domain

pfam17921
Location:68 → 120

Integrase_H2C2; Integrase zinc binding domain

cl29137
Location:367 → 421

Trypan_PARP; Procyclic acidic repetitive protein (PARP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

55791820..55829276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159968.1 → XP_036015861.1 zinc finger and BTB domain-containing protein 11 isoform X1

Conserved Domains (6) summary

PRK12387
Location:554 → 621

PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional

sd00017
Location:848 → 868

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18202
Location:195 → 312

BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)

pfam13465
Location:888 → 911

zf-H2C2_2; Zinc-finger double domain

pfam17921
Location:68 → 120

Integrase_H2C2; Integrase zinc binding domain

NF033845
Location:371 → 502

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_030249142.2 → XP_030105002.1 zinc finger and BTB domain-containing protein 11 isoform X2

Conserved Domains (7) summary

PRK12387
Location:554 → 621

PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional

COG5189
Location:667 → 752

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:678 → 698

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18202
Location:195 → 312

BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)

pfam13465
Location:662 → 687

zf-H2C2_2; Zinc-finger double domain

pfam17921
Location:68 → 120

Integrase_H2C2; Integrase zinc binding domain

cl29137
Location:367 → 421

Trypan_PARP; Procyclic acidic repetitive protein (PARP)
XM_036159969.1 → XP_036015862.1 zinc finger and BTB domain-containing protein 11 isoform X3

Conserved Domains (5) summary

COG5048
Location:380 → 553

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:394 → 414

ZF_C2H2; C2H2 Zn finger [structural motif]

cl38908
Location:1 → 28

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam13465
Location:613 → 636

zf-H2C2_2; Zinc-finger double domain

NF033845
Location:87 → 218

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB