Bglap2 bone gamma-carboxyglutamate protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bglap2provided by MGI
Official Full Name: bone gamma-carboxyglutamate protein 2provided by MGI
Primary source: MGI:MGI:88157
See related: Ensembl:ENSMUSG00000074486 AllianceGenome:MGI:88157
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bgp; Og2; BGP2; mOC-B; Bglap1
Summary: This gene encodes a preproprotein that is proteolytically processed to generate a mature protein product. This protein product is a hormone that is secreted by osteoblasts and may function in bone remodeling and energy metabolism. Homozygous knockout mice for this gene exhibit a gradual increase in bone size, density and strength, as well as elevated adiposity and impaired glucose tolerance. This gene is present in a gene cluster with other related genes on chromosome 3. [provided by RefSeq, Aug 2015]
Expression: Biased expression in genital fat pad adult (RPKM 23.2), stomach adult (RPKM 16.5) and 8 other tissues See more
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Genomic context

Location:: 3 F1; 3 38.81 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88285043..88286008, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88377736..88378701, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 bglap-bglap2 Deficiency Mouse Model.
Title: Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9 bglap-bglap2 Deficiency Mouse Model.
Osteocalcin improves glucose tolerance, insulin sensitivity and secretion in older male mice.
Title: Osteocalcin improves glucose tolerance, insulin sensitivity and secretion in older male mice.
Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet.
Title: Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet.
Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring.
Title: Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring.
Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice.
Title: Exercise ameliorates anxious behavior and promotes neuroprotection through osteocalcin in VCD-induced menopausal mice.
Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse.
Title: Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse.
Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin.
Title: Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin.
Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity.
Title: Male but not female mice with severe osteogenesis imperfecta are partially protected from high-fat diet-induced obesity.
Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
Title: Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis.
Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia.
Title: Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Bglap1 (e-PCR), detects polymorphism
- UniSTS:280395

PMC34669P2 (e-PCR)
- UniSTS:273228

Bglap1 (e-PCR), detects polymorphism
- UniSTS:141174

Bglap-rs1 (e-PCR), detects polymorphism
- UniSTS:256998

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydroxyapatite binding	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxyapatite binding	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of bone	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of bone	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of bone	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in bone development	IBA Inferred from Biological aspect of Ancestor more info
involved_in bone development	IEA Inferred from Electronic Annotation more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in regulation of testosterone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to vitamin K	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type B pancreatic cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: osteocalcin-2

Names: bone Gla protein 2; gamma-carboxyglutamic acid-containing protein 2; osteocalcin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.