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    Mllt1 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 [ Mus musculus (house mouse) ]

    Gene ID: 64144, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mllt1provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1provided by MGI
    Primary source
    MGI:MGI:1927238
    See related
    Ensembl:ENSMUSG00000024212 AllianceGenome:MGI:1927238
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENL; BAM11; LTG19
    Summary
    Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Acts upstream of or within negative regulation of protein kinase activity. Located in nucleus. Is expressed in several structures, including brain; branchial arch; limb; maxillary process; and sensory organ. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 43.0), ovary adult (RPKM 41.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mllt1 in Genome Data Viewer
    Location:
    17 D; 17 29.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57199611..57242497, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56892608..56935509, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene STARR-seq mESC enhancer starr_42911 Neighboring gene acyl-CoA synthetase bubblegum family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E1946 Neighboring gene alkaline ceramidase 1 Neighboring gene predicted gene, 33509

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding  
    enables lysine-acetylated histone binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    located_in fibrillar center  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    part_of transcription elongation factor complex  
    part_of transcription elongation factor complex  

    General protein information

    Preferred Names
    protein ENL
    Names
    leukemia-associated protein MLLT1
    myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
    myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
    trithorax

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410196.1NP_001397125.1  protein ENL isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC073683
      UniProtKB/TrEMBL
      Q8CJ76
    2. NM_001410198.1NP_001397127.1  protein ENL isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC073683
    3. NM_022328.3NP_071723.1  protein ENL isoform 1

      See identical proteins and their annotated locations for NP_071723.1

      Status: VALIDATED

      Source sequence(s)
      AC073683
      Consensus CDS
      CCDS28918.1
      UniProtKB/TrEMBL
      Q8CJ76, Q9ERL0
      Related
      ENSMUSP00000025053.9, ENSMUST00000025053.10
      Conserved Domains (2) summary
      pfam03366
      Location:29109
      YEATS; YEATS family
      pfam05110
      Location:152335
      AF-4; AF-4 proto-oncoprotein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57199611..57242497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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