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    Zfp85 zinc finger protein 85 [ Mus musculus (house mouse) ]

    Gene ID: 22746, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp85provided by MGI
    Official Full Name
    zinc finger protein 85provided by MGI
    Primary source
    MGI:MGI:107767
    See related
    Ensembl:ENSMUSG00000058331 AllianceGenome:MGI:107767
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp71; KRAB19; Rslcan2; Zfp85-rs1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF678 (zinc finger protein 678) and ZNF708 (zinc finger protein 708). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E14 (RPKM 2.0), CNS E18 (RPKM 1.9) and 22 other tissues See more
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    Genomic context

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    See Zfp85 in Genome Data Viewer
    Location:
    13 B3; 13 34.74 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67892583..67903321, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67744464..67755202, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 738 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67784456-67784643 Neighboring gene zinc finger protein 65 Neighboring gene STARR-seq mESC enhancer starr_34907 Neighboring gene zinc finger protein 85, opposite strand Neighboring gene STARR-seq mESC enhancer starr_34908 Neighboring gene STARR-seq mESC enhancer starr_34909 Neighboring gene STARR-seq mESC enhancer starr_34910 Neighboring gene zinc finger protein 85, related sequence 1 pseudogene Neighboring gene zinc finger protein 493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    4. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 85
    Names
    KRAB-zinc finger protein 71
    regulator of sex-limitation candidate 2
    zinc finger protein 85, related sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001130.3 → NP_001001130.1  zinc finger protein 85

      See identical proteins and their annotated locations for NP_001001130.1

      Status: VALIDATED

      Source sequence(s)
      BC055337, BK001637, DV658296
      Consensus CDS
      CCDS36717.1
      UniProtKB/TrEMBL
      B8JJY3, Q7TMC9
      Related
      ENSMUSP00000121202.3, ENSMUST00000144183.3
      Conserved Domains (5) summary
      smart00349
      Location:5 → 65
      KRAB; krueppel associated box
      COG5048
      Location:79 → 464
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:83 → 103
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:375 → 400
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67892583..67903321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247245.2 → XP_030103105.1  zinc finger protein 85 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:74 → 439
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:50 → 70
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. XM_036158035.1 → XP_036013928.1  zinc finger protein 85 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:45 → 90
      KRAB; krueppel associated box
      COG5048
      Location:115 → 480
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:91 → 111
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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