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    Slc41a3 solute carrier family 41, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 71699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc41a3provided by MGI
    Official Full Name
    solute carrier family 41, member 3provided by MGI
    Primary source
    MGI:MGI:1918949
    See related
    Ensembl:ENSMUSG00000030089 AllianceGenome:MGI:1918949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SLC41A1-L2; 1010001P06Rik
    Summary
    Predicted to enable magnesium:sodium antiporter activity. Predicted to be involved in mitochondrial magnesium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system; eye; hemolymphoid system; liver; and nervous system. Orthologous to human SLC41A3 (solute carrier family 41 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 26.9), testis adult (RPKM 24.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc41a3 in Genome Data Viewer
    Location:
    6 D1; 6 40.16 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90579043..90623394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90604730..90646412)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Kruppel-like transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_16625 Neighboring gene STARR-seq mESC enhancer starr_16627 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene STARR-positive B cell enhancer ABC_E8115 Neighboring gene predicted gene 15756 Neighboring gene predicted gene, 53296 Neighboring gene IQ motif and Sec7 domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E8116 Neighboring gene STARR-seq mESC enhancer starr_16629 Neighboring gene STARR-positive B cell enhancer ABC_E6454 Neighboring gene STARR-positive B cell enhancer ABC_E10393 Neighboring gene VISTA enhancer mm1470 Neighboring gene STARR-positive B cell enhancer ABC_E10394 Neighboring gene ribosomal protein L21, pseudogene 12 Neighboring gene predicted gene, 25185

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of SLC41A3 as a novel player in magnesium homeostasis. de Baaij JH, et al. Sci Rep, 2016 Jun 28. PMID 27349617, Free PMC Article
    2. SLC41A1 knockout mice display normal magnesium homeostasis. Ilenwabor BP, et al. Am J Physiol Renal Physiol, 2022 Nov 1. PMID 36049064
    3. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
    4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC41A3 was established as a new factor for Mg(2+) handling.
      Title: Identification of SLC41A3 as a novel player in magnesium homeostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables magnesium:sodium antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium:sodium antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial magnesium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial magnesium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 41 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037493.2 → NP_001032570.1  solute carrier family 41 member 3 isoform 2

      See identical proteins and their annotated locations for NP_001032570.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compated to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK003140, BQ176613
      Consensus CDS
      CCDS20363.1
      UniProtKB/Swiss-Prot
      Q921R8, Q9DC67
      Related
      ENSMUSP00000032177.9, ENSMUST00000032177.10
      Conserved Domains (1) summary
      pfam01769
      Location:80 → 211
      MgtE; Divalent cation transporter

    2. NM_027868.2 → NP_082144.2  solute carrier family 41 member 3 isoform 1

      See identical proteins and their annotated locations for NP_082144.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK003140, AW492407, BB872292, BY108317, CN699671
      Consensus CDS
      CCDS20362.1
      UniProtKB/Swiss-Prot
      Q921R8, Q9DC67
      UniProtKB/TrEMBL
      G3X937
      Related
      ENSMUSP00000037473.10, ENSMUST00000044019.16
      Conserved Domains (1) summary
      pfam01769
      Location:106 → 238
      MgtE; Divalent cation transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      90579043..90623394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152308.1 → XP_036008201.1  solute carrier family 41 member 3 isoform X1

      UniProtKB/Swiss-Prot
      Q921R8, Q9DC67
      UniProtKB/TrEMBL
      G3X937
      Conserved Domains (1) summary
      pfam01769
      Location:106 → 238
      MgtE; Divalent cation transporter

    2. XM_006506625.3 → XP_006506688.1  solute carrier family 41 member 3 isoform X2

      UniProtKB/Swiss-Prot
      Q921R8, Q9DC67
      Conserved Domains (1) summary
      pfam01769
      Location:270 → 412
      MgtE; Divalent cation transporter

    3. XM_030255596.2 → XP_030111456.1  solute carrier family 41 member 3 isoform X5

      Conserved Domains (1) summary
      pfam01769
      Location:153 → 295
      MgtE; Divalent cation transporter

    4. XM_006506627.5 → XP_006506690.1  solute carrier family 41 member 3 isoform X4

      Conserved Domains (1) summary
      pfam01769
      Location:4 → 136
      MgtE; Divalent cation transporter

    5. XM_006506626.5 → XP_006506689.1  solute carrier family 41 member 3 isoform X3

      UniProtKB/Swiss-Prot
      Q921R8, Q9DC67
      Conserved Domains (1) summary
      pfam01769
      Location:27 → 159
      MgtE; Divalent cation transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921R8.1 GenPept UniProtKB/Swiss-Prot:Q921R8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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