Defa6 defensin, alpha, 6 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Defa6provided by MGI
Official Full Name: defensin, alpha, 6provided by MGI
Primary source: MGI:MGI:99582
See related: AllianceGenome:MGI:99582
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Defcr6
Summary: Predicted to enable pore-forming activity and protein homodimerization activity. Acts upstream of or within response to bacterium and response to xenobiotic stimulus. Located in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA1B (defensin alpha 1B); and DEFA5 (defensin alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: not in current annotation release
Orthologs: human all
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Genomic context

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Location:: 8; 8 A2

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
Title: The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pore-forming activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-negative bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in disruption of plasma membrane integrity in another organism	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response in mucosa	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-defensin 6/12

Names: alpha-defensin, 6; cryptdin-2; defensin related cryptdin 6; defensin-related cryptdin-6/12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007852.1 → NP_031878.1 alpha-defensin 6/12 precursor

See identical proteins and their annotated locations for NP_031878.1

Status: VALIDATED

Source sequence(s)

AH005402

UniProtKB/Swiss-Prot

P50704, P50710, P50714, P82294

Conserved Domains (2) summary

pfam00323
Location:64 → 92

Defensin_1; Mammalian defensin

pfam00879
Location:14 → 51

Defensin_propep; Defensin propeptide