LUZP4 leucine zipper protein 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LUZP4provided by HGNC
Official Full Name: leucine zipper protein 4provided by HGNC
Primary source: HGNC:HGNC:24971
See related: Ensembl:ENSG00000102021 MIM:300616; AllianceGenome:HGNC:24971
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CT-8; CT28; CT-28; HOM-TES-85
Summary: This gene encodes a leucine-zipper protein that was first defined as a cancer testis antigens. The encoded protein is an RNA binding protein that interacts with the mRNA export receptor nuclear RNA export factor 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression: Restricted expression toward testis (RPKM 5.6) See more
Orthologs: all
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Genomic context

Location:: Xq23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (115289715..115307563)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (113698307..113716155)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (114524281..114542128)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Luzp4 is an RNA-binding protein which associates with the TREX mRNA export complex subunit Uap56. Luzp4 also binds the principal mRNA export receptor Nxf1, enhances its RNA binding activity and complements Alyref knockdown in vivo. Luzp4 displays all features of an mRNA export adaptor. Whilst Luzp4 is up-regulated in a range of tumours, it appears preferentially expressed in melanoma cells where it is required for growth.
Title: Luzp4 defines a new mRNA export pathway in cancer cells.
A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing.
Title: A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine zipper protein 4

Names: HOM-TES-85 tumor antigen; cancer/testis antigen 28; tumor antigen HOM-TES-85

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021297.2 RefSeqGene

Range

4995..22843

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001318840.2 → NP_001305769.1 leucine zipper protein 4 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in the use of a an alternate 5' most exon and a frameshift in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AC239923, AF124430, AK093369, DB035084

UniProtKB/Swiss-Prot

Q9P127

Conserved Domains (1) summary

pfam12316
Location:48 → 147

Dsh_C; Segment polarity protein dishevelled (Dsh) C terminal
NM_016383.5 → NP_057467.1 leucine zipper protein 4 isoform 1

See identical proteins and their annotated locations for NP_057467.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC239923, AF124430, AK093369, DB035084

Consensus CDS

CCDS14567.1

UniProtKB/Swiss-Prot

B3KSD6, Q9P127

Related

ENSP00000360988.3, ENST00000371920.4

Conserved Domains (1) summary

pfam07078
Location:14 → 116

FYTT; Forty-two-three protein