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    Reg2 regenerating islet-derived 2 [ Mus musculus (house mouse) ]

    Gene ID: 19693, updated on 9-Dec-2024

    Summary

    Official Symbol
    Reg2provided by MGI
    Official Full Name
    regenerating islet-derived 2provided by MGI
    Primary source
    MGI:MGI:97896
    See related
    Ensembl:ENSMUSG00000023140 AllianceGenome:MGI:97896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSP; PTP; REG-2
    Summary
    Predicted to enable several functions, including molecular function inhibitor activity; oligosaccharide binding activity; and peptidoglycan binding activity. Acts upstream of or within myelination and suckling behavior. Located in collagen-containing extracellular matrix. Is expressed in several structures, including gut; male reproductive gland or organ; and mesenteric adipose tissue. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward small intestine adult (RPKM 155.3) See more
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    Genomic context

    See Reg2 in Genome Data Viewer
    Location:
    6 C3; 6 34.77 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (78382138..78385082)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (78405155..78408099)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived 3 delta Neighboring gene regenerating islet-derived 3 alpha Neighboring gene STARR-seq mESC enhancer starr_16390 Neighboring gene regenerating islet-derived 1 Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC107500

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular function inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within suckling behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    lithostathine-2
    Names
    islet of Langerhans regenerating protein 2
    pancreatic stone protein 2
    pancreatic thread protein 2
    regenerating islet-derived, mouse homolog 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009043.2NP_033069.1  lithostathine-2 precursor

      See identical proteins and their annotated locations for NP_033069.1

      Status: VALIDATED

      Source sequence(s)
      AC113058, AK008196, BC098503
      Consensus CDS
      CCDS20256.1
      UniProtKB/Swiss-Prot
      Q08731
      UniProtKB/TrEMBL
      Q545J0
      Related
      ENSMUSP00000023906.3, ENSMUST00000023906.4
      Conserved Domains (1) summary
      cl02432
      Location:43171
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      78382138..78385082
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)