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    Tacr1 tachykinin receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 21336, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tacr1provided by MGI
    Official Full Name
    tachykinin receptor 1provided by MGI
    Primary source
    MGI:MGI:98475
    See related
    Ensembl:ENSMUSG00000030043 AllianceGenome:MGI:98475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spr; Nk1r; Tac1r
    Summary
    This gene encodes the receptor for the tachykinin, substance P, also referred to as neurokinin 1. This gene belongs to a gene family of tachykinin receptors which are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This receptor has been associated with nitric oxide formation, and it has been localized to cholinergic and nitrergic neurons as well as on smooth muscle cells. [provided by RefSeq, Mar 2010]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tacr1 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82378990..82537085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82402003..82560104)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40381 Neighboring gene STARR-seq mESC enhancer starr_16424 Neighboring gene predicted gene, 53289 Neighboring gene STARR-seq mESC enhancer starr_16425 Neighboring gene STARR-seq mESC enhancer starr_16429 Neighboring gene STARR-positive B cell enhancer ABC_E6445 Neighboring gene polymerase (DNA-directed), epsilon 4 (p12 subunit) Neighboring gene STARR-seq mESC enhancer starr_16430 Neighboring gene STARR-seq mESC enhancer starr_16435 Neighboring gene predicted gene, 32425

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (8) 
    • Targeted (10)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables substance P receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables substance P receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables substance P receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in aggressive behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aggressive behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in angiotensin-mediated drinking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in angiotensin-mediated drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in associative learning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in associative learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in behavioral response to pain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in behavioral response to pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in operant conditioning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in operant conditioning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of action potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of action potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of flagellated sperm motility IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lymphocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, GABAergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of uterine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular permeability IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular permeability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of uterine smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to auditory stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to auditory stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ozone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ozone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle contraction involved in micturition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in smooth muscle contraction involved in micturition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sperm ejaculation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sperm ejaculation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tachykinin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tachykinin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm head IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sperm midpiece IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    substance-P receptor
    Names
    Nk1 receptor
    neurokinin receptor 1
    substance P receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009313.5NP_033339.2  substance-P receptor

      See identical proteins and their annotated locations for NP_033339.2

      Status: REVIEWED

      Source sequence(s)
      AC159655, BC075631, BC098332
      Consensus CDS
      CCDS20262.1
      UniProtKB/Swiss-Prot
      P30548, Q8BYR7
      Related
      ENSMUSP00000032122.8, ENSMUST00000032122.11
      Conserved Domains (2) summary
      cd14964
      Location:3559
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33316
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      82378990..82537085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505863.4XP_006505926.1  substance-P receptor isoform X1

      See identical proteins and their annotated locations for XP_006505926.1

      UniProtKB/Swiss-Prot
      P30548, Q8BYR7
      Conserved Domains (2) summary
      cd14964
      Location:3559
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33316
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. XM_006505864.5XP_006505927.1  substance-P receptor isoform X1

      See identical proteins and their annotated locations for XP_006505927.1

      UniProtKB/Swiss-Prot
      P30548, Q8BYR7
      Conserved Domains (2) summary
      cd14964
      Location:3559
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33316
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006505865.4XP_006505928.1  substance-P receptor isoform X1

      See identical proteins and their annotated locations for XP_006505928.1

      UniProtKB/Swiss-Prot
      P30548, Q8BYR7
      Related
      ENSMUSP00000145217.2, ENSMUST00000203775.2
      Conserved Domains (2) summary
      cd14964
      Location:3559
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33316
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily