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    Reg3g regenerating islet-derived 3 gamma [ Mus musculus (house mouse) ]

    Gene ID: 19695, updated on 9-Dec-2024

    Summary

    Official Symbol
    Reg3gprovided by MGI
    Official Full Name
    regenerating islet-derived 3 gammaprovided by MGI
    Primary source
    MGI:MGI:109406
    See related
    Ensembl:ENSMUSG00000030017 AllianceGenome:MGI:109406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    REG-3-gamma; reg III-gamma
    Summary
    This gene encodes a C-type lectin that demonstrates bactericidal activity. This gene is predominantly expressed in the distal small intestine where the encoded protein undergoes proteolytic processing by trypsin. Mice lacking the encoded protein exhibit altered mucus distribution, increased bacterial contact with the epithelium, and elevated inflammatory markers in the ileum, and low-grade inflammation. [provided by RefSeq, Jun 2016]
    Expression
    Restricted expression toward large intestine adult (RPKM 6323.4) See more
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    Genomic context

    See Reg3g in Genome Data Viewer
    Location:
    6 C3; 6 34.78 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (78443252..78445857, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (78466269..78468874, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived 1 Neighboring gene nuclease-sensitive element-binding protein 1 pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 6_789.1 Neighboring gene STARR-seq mESC enhancer starr_16392 Neighboring gene STARR-seq mESC enhancer starr_16394 Neighboring gene STARR-seq mESC enhancer starr_16395 Neighboring gene predicted gene, 23727

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hormone activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oligosaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in MyD88-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of keratinocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of detection of glucose IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of keratinocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to symbiotic bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regenerating islet-derived protein 3-gamma
    Names
    generating islet-derived, mouse homolog 3 gamma
    pancreatitis-associated protein 3
    regenerating islet-derived protein III-gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011260.2NP_035390.1  regenerating islet-derived protein 3-gamma preproprotein

      See identical proteins and their annotated locations for NP_035390.1

      Status: REVIEWED

      Source sequence(s)
      BF020649, D63361
      Consensus CDS
      CCDS20258.1
      UniProtKB/Swiss-Prot
      O09049
      UniProtKB/TrEMBL
      Q545I1
      Related
      ENSMUSP00000032089.3, ENSMUST00000032089.3
      Conserved Domains (1) summary
      cd03594
      Location:40172
      CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      78443252..78445857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)