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    Reg3a regenerating islet-derived 3 alpha [ Mus musculus (house mouse) ]

    Gene ID: 19694, updated on 9-Dec-2024

    Summary

    Official Symbol
    Reg3aprovided by MGI
    Official Full Name
    regenerating islet-derived 3 alphaprovided by MGI
    Primary source
    MGI:MGI:109408
    See related
    Ensembl:ENSMUSG00000079516 AllianceGenome:MGI:109408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including hormone activity; identical protein binding activity; and peptidoglycan binding activity. Involved in negative regulation of keratinocyte differentiation; positive regulation of keratinocyte proliferation; and positive regulation of wound healing. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in gut and pancreas. Orthologous to human REG3A (regenerating family member 3 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 62.2), duodenum adult (RPKM 50.2) and 1 other tissue See more
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    Genomic context

    See Reg3a in Genome Data Viewer
    Location:
    6 C3; 6 34.76 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (78357692..78360822)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (78380709..78383839)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived 3 beta Neighboring gene regenerating islet-derived 3 delta Neighboring gene regenerating islet-derived 2 Neighboring gene STARR-seq mESC enhancer starr_16390 Neighboring gene regenerating islet-derived 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    regenerating islet-derived protein 3-alpha
    Names
    REG-3-alpha
    RegIII (alpha)
    generating islet-derived, mouse homolog 3 alpha
    islet of Langerhans regenerating protein 3
    lithostathine 3
    pancreatitis-associated protein 2
    reg III-alpha
    regenerating islet-derived protein III-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011259.1NP_035389.1  regenerating islet-derived protein 3-alpha precursor

      Status: PROVISIONAL

      Source sequence(s)
      D63358
      Consensus CDS
      CCDS20255.1
      UniProtKB/Swiss-Prot
      O09037
      UniProtKB/TrEMBL
      Q794C6, Q9CVF4
      Related
      ENSMUSP00000098829.2, ENSMUST00000101272.3
      Conserved Domains (1) summary
      cl02432
      Location:40173
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      78357692..78360822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)