ADD1 adducin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADD1provided by HGNC
Official Full Name: adducin 1provided by HGNC
Primary source: HGNC:HGNC:243
See related: Ensembl:ENSG00000087274 MIM:102680; AllianceGenome:HGNC:243
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADDA
Summary: Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in brain (RPKM 57.3), ovary (RPKM 51.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p16.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (2843844..2930062)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (2842299..2928525)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (2845571..2931789)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alpha-adducin 1 (rs4961) gene and its expression associated with sodium sensitivity in hypertensive patients: a cohort study in the western Ukrainian population.
Title: Alpha-adducin 1 (rs4961) gene and its expression associated with sodium sensitivity in hypertensive patients: a cohort study in the western Ukrainian population.
The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.
Title: The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.
Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.
Title: Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.
Letter to the editor: Association between alpha-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.
Title: Letter to the editor: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.
Increased expression of phosphorylated adducin in tumor cells.
Title: Increased expression of phosphorylated adducin in tumor cells.
Variant T allele of ADD1 gene may be considered as the risk factor for the development of diabetes in hypertensive patients. Diuretics as mono therapy and in combination with BBs may be considered as the risk factor for new onset of diabetes in EH patients carrying variant T allele (either as TG or TT).
Title: Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension.
findings indicate that the alpha-adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.
Title: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.
These findings unveil a novel function of ADD1 in maintaining spindle pole integrity through its interaction with TPX2.
Title: Adducin-1 is essential for spindle pole integrity through its interaction with TPX2.
alpha-adducing SNPs were not associated with bone density among lead workers.
Title: Use of Genetic Algorithm Combinational Single-nucleotide Polymorphisms Could Modify the Association of Blood Lead Levels and Bone Matrix Density.
These findings highlight that ADD1 methylation may have a contributing role in the pathogenesis of EH with varying implications for both genders.
Title: α-Adducin gene promoter DNA methylation and the risk of essential hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (121)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Essential hypertension, genetic MedGen: CN305331 OMIM: 145500 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G21856 (e-PCR)
- UniSTS:79115

L17688 (e-PCR)
- UniSTS:74509

GDB:197234 (e-PCR)
- UniSTS:155930

SHGC-31191 (e-PCR)
- UniSTS:38431

SHGC-50709 (e-PCR)
- UniSTS:803

SGC38240 (e-PCR)
- UniSTS:60719

SHGC-59535 (e-PCR)
- UniSTS:33081

D1S1423 (e-PCR)
- UniSTS:149619

RH80030 (e-PCR)
- UniSTS:87680

G16715 (e-PCR)
- UniSTS:44431

SHGC-59864 (e-PCR)
- UniSTS:55191

D4S2503E (e-PCR)
- UniSTS:150963

IB433 (e-PCR)
- UniSTS:71609

SHGC-67376 (e-PCR)
- UniSTS:24026

SHGC-59534 (e-PCR)
- UniSTS:78051

SHGC-67653 (e-PCR)
- UniSTS:33274

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IC Inferred by Curator more info	PubMed
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of adherens junction organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of establishment of endothelial barrier	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-adducin

Names: adducin 1 (alpha); alpha-adducin 1; erythrocyte adducin alpha subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012037.1 RefSeqGene

Range

4988..91206

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001119.5 → NP_001110.2 alpha-adducin isoform a

See identical proteins and their annotated locations for NP_001110.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) utilizes an in-frame alternate splice site in the coding region, compared to variant 2. This results in a shorter protein (isoform a), compared to isoform b. Variants 1, 6, and 7 all encode the same isoform (a).

Source sequence(s)

AL121750, BI460192, CR995783, CX783962, X58141

Consensus CDS

CCDS43205.1

UniProtKB/Swiss-Prot

A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6

UniProtKB/TrEMBL

E7ENY0

Related

ENSP00000381197.1, ENST00000398129.5

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:584 → 702

BASP1; Brain acid soluble protein 1 (BASP1 protein)
NM_001286645.2 → NP_001273574.1 alpha-adducin isoform e

See identical proteins and their annotated locations for NP_001273574.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and contains two additional alternate exons compared to variant 1. The resulting isoform (e) has an alternate in-frame segment and a shorter and distinct C-terminus compared to isoform a. Variants 5 and 11 both encode the same isoform (e).

Source sequence(s)

BC042998, BU729599

Consensus CDS

CCDS75094.1

UniProtKB/TrEMBL

E7ENY0

Related

ENSP00000348100.3, ENST00000355842.7

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001354754.2 → NP_001341683.1 alpha-adducin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (6), as well as variants 1 and 7, encodes isoform a.

Source sequence(s)

AL121750, AL390065, BX465861

Consensus CDS

CCDS43205.1

UniProtKB/Swiss-Prot

A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:584 → 702

BASP1; Brain acid soluble protein 1 (BASP1 protein)
NM_001354755.2 → NP_001341684.1 alpha-adducin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (7), as well as variants 1 and 6, encodes isoform a.

Source sequence(s)

AL121750, AL390065, BX465861

Consensus CDS

CCDS43205.1

UniProtKB/Swiss-Prot

A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:584 → 702

BASP1; Brain acid soluble protein 1 (BASP1 protein)
NM_001354756.2 → NP_001341685.1 alpha-adducin isoform f

Status: REVIEWED

Source sequence(s)

AL121750, AL390065, BX465861

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl27087
Location:624 → 725

SPOR; Sporulation related domain
NM_001354757.2 → NP_001341686.1 alpha-adducin isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (9), as well as variants 3 and 10, encodes isoform c.

Source sequence(s)

AL121750, AL390065, BX465861

Consensus CDS

CCDS93468.1

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001354758.2 → NP_001341687.1 alpha-adducin isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (10), as well as variants 3 and 9, encodes isoform c.

Source sequence(s)

AL121750, AL390065, BX465861

Consensus CDS

CCDS93468.1

UniProtKB/TrEMBL

E7ENY0

Related

ENSP00000498269.1, ENST00000651918.1

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001354759.2 → NP_001341688.1 alpha-adducin isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (11), as well as variant 5, encodes isoform e.

Source sequence(s)

AL121750, AL390065, BX465861

Consensus CDS

CCDS75094.1

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001354761.2 → NP_001341690.1 alpha-adducin isoform g

Status: REVIEWED

Description

Transcript Variant: This variant (12) encodes the longest isoform (g).

Source sequence(s)

AL121750, AL390065, BX465861

Consensus CDS

CCDS93469.1

UniProtKB/TrEMBL

A0A804HL01, E7ENY0

Related

ENSP00000508142.1, ENST00000683351.1

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:646 → 764

BASP1; Brain acid soluble protein 1 (BASP1 protein)
NM_001354762.2 → NP_001341691.1 alpha-adducin isoform h

Status: REVIEWED

Source sequence(s)

AL121750, AL390065, BX465861

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_014189.4 → NP_054908.2 alpha-adducin isoform b

See identical proteins and their annotated locations for NP_054908.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) encodes isoform b.

Source sequence(s)

AL121750, BI460192, CA391117, CR995783, CX783962, X58141

Consensus CDS

CCDS3363.1

UniProtKB/TrEMBL

E7ENY0

Related

ENSP00000264758.6, ENST00000264758.11

Conserved Domains (2) summary

pfam05466
Location:615 → 733

BASP1; Brain acid soluble protein 1 (BASP1 protein)

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_014190.4 → NP_054909.2 alpha-adducin isoform c

See identical proteins and their annotated locations for NP_054909.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes an additional exon in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded protein (isoform c) contains an early stop codon and shorter C-terminus, compared to isoform b. Variants 3, 9, and 10 all encode the same isoform (c).

Source sequence(s)

AL121750, BC042998, BI460192, BU729599, CR995783, X58141

Consensus CDS

CCDS93468.1

UniProtKB/TrEMBL

E7ENY0

Related

ENSP00000421907.2, ENST00000513328.6

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_176801.3 → NP_789771.1 alpha-adducin isoform d

See identical proteins and their annotated locations for NP_789771.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) utilizes an alternate splice site and includes an additional exon in the coding region, which results in a frameshift, compared to variant 2. The encoded protein (isoform d) contains an early stop codon and shorter C-terminus, compared to isoform b.

Source sequence(s)

AL121750, BC042998, BI460192, BU729599, CA391117, CR995783, X58141

Consensus CDS

CCDS3364.1

UniProtKB/TrEMBL

E7ENY0

Related

ENSP00000381193.1, ENST00000398125.5

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

2843844..2930062

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047449580.1 → XP_047305536.1 alpha-adducin isoform X1

UniProtKB/TrEMBL

A0A804HL01, E7ENY0
XM_047449581.1 → XP_047305537.1 alpha-adducin isoform X1

UniProtKB/TrEMBL

A0A804HL01, E7ENY0
XM_047449579.1 → XP_047305535.1 alpha-adducin isoform X1

UniProtKB/TrEMBL

A0A804HL01, E7ENY0
XM_047449582.1 → XP_047305538.1 alpha-adducin isoform X3

UniProtKB/TrEMBL

E7ENY0
XM_017007703.2 → XP_016863192.1 alpha-adducin isoform X1

UniProtKB/TrEMBL

A0A804HL01, E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:646 → 764

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_005247934.3 → XP_005247991.1 alpha-adducin isoform X1

See identical proteins and their annotated locations for XP_005247991.1

UniProtKB/TrEMBL

A0A804HL01, E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:646 → 764

BASP1; Brain acid soluble protein 1 (BASP1 protein)
XM_024453887.2 → XP_024309655.1 alpha-adducin isoform X5

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_017007704.2 → XP_016863193.1 alpha-adducin isoform X2

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (2) summary

pfam05466
Location:615 → 733

BASP1; Brain acid soluble protein 1 (BASP1 protein)

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_017007705.2 → XP_016863194.1 alpha-adducin isoform X3

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl27087
Location:624 → 725

SPOR; Sporulation related domain
XM_017007709.3 → XP_016863198.1 alpha-adducin isoform X6

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_017007706.3 → XP_016863195.1 alpha-adducin isoform X4

UniProtKB/Swiss-Prot

A2A3N8, A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, P35611, Q13734, Q14729, Q16156, Q86XM2, Q9UJB6

UniProtKB/TrEMBL

E7ENY0

Conserved Domains (2) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

cl25756
Location:584 → 702

BASP1; Brain acid soluble protein 1 (BASP1 protein)