STIP1 stress induced phosphoprotein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STIP1provided by HGNC
Official Full Name: stress induced phosphoprotein 1provided by HGNC
Primary source: HGNC:HGNC:11387
See related: Ensembl:ENSG00000168439 MIM:605063; AllianceGenome:HGNC:11387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521
Summary: STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Expression: Ubiquitous expression in testis (RPKM 66.9), adrenal (RPKM 34.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (64185272..64204543)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (64175217..64194489)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (63952744..63972015)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study.
Title: Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study.
LINC01226 promotes gastric cancer progression through enhancing cytoplasm-to-nucleus translocation of STIP1 and stabilizing beta-catenin protein.
Title: LINC01226 promotes gastric cancer progression through enhancing cytoplasm-to-nucleus translocation of STIP1 and stabilizing β-catenin protein.
Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1.
Title: Tumor-promoting action of ubiquitin protease 43 in gastric cancer progression through deubiquitination and stabilization of stress-inducible phosphoprotein 1.
JAK2-Mediated Phosphorylation of Stress-Induced Phosphoprotein-1 (STIP1) in Human Cells.
Title: JAK2-Mediated Phosphorylation of Stress-Induced Phosphoprotein-1 (STIP1) in Human Cells.
The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration.
Title: The Hsp70-Hsp90 go-between Hop/Stip1/Sti1 is a proteostatic switch and may be a drug target in cancer and neurodegeneration.
Stress-induced phosphoprotein 1 facilitates breast cancer cell progression and indicates poor prognosis for breast cancer patients.
Title: Stress-induced phosphoprotein 1 facilitates breast cancer cell progression and indicates poor prognosis for breast cancer patients.
GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.
Title: GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.
Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders.
Title: Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders.
Expanding the clinical spectrum of STIP1 homology and U-box containing protein 1-associated ataxia.
Title: Expanding the clinical spectrum of STIP1 homology and U-box containing protein 1-associated ataxia.
Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.
Title: Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.

Submit: New GeneRIF Correction See all GeneRIFs (63)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of the child behavior checklist dysregulation profile. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of stress-induced-phosphoprotein 1 (STIP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, stress-induced-phosphoprotein 1 (STIP1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of stress-induced-phosphoprotein 1 (STIP1) in the nucleoli of Jurkat T-cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S4364 (e-PCR)
- UniSTS:44336

RH11478 (e-PCR)
- UniSTS:11837

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to interleukin-7	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of protein folding chaperone complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: stress-induced-phosphoprotein 1

Names: Hsp70/Hsp90-organizing protein; NY-REN-11 antigen; epididymis secretory sperm binding protein Li 94n; hsc70/Hsp90-organizing protein; renal carcinoma antigen NY-REN-11; transformation-sensitive protein IEF SSP 3521

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282652.2 → NP_001269581.1 stress-induced-phosphoprotein 1 isoform a

See identical proteins and their annotated locations for NP_001269581.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

BC039299, DA123899, DA781468

Consensus CDS

CCDS60827.1

UniProtKB/TrEMBL

A8K690

Related

ENSP00000351646.5, ENST00000358794.9

Conserved Domains (2) summary

sd00006
Location:411 → 435

TPR; TPR repeat [structural motif]

cl26005
Location:54 → 579

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
NM_001282653.2 → NP_001269582.1 stress-induced-phosphoprotein 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, uses an alternate start codon, and contains an in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AK297319, BC039299, DA781468

Consensus CDS

CCDS60828.1

UniProtKB/TrEMBL

A8K690

Related

ENSP00000445957.1, ENST00000538945.5

Conserved Domains (6) summary

smart00727
Location:468 → 507

STI1; Heat shock chaperonin-binding motif

smart00028
Location:276 → 304

TPR; Tetratricopeptide repeats

sd00006
Location:340 → 364

TPR; TPR repeat [structural motif]

pfam00515
Location:370 → 403

TPR_1; Tetratricopeptide repeat

pfam13414
Location:336 → 401

TPR_11; TPR repeat

pfam13424
Location:231 → 304

TPR_12; Tetratricopeptide repeat
NM_006819.3 → NP_006810.1 stress-induced-phosphoprotein 1 isoform b

See identical proteins and their annotated locations for NP_006810.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 5' terminal exon and thus differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

DA781468, M86752

Consensus CDS

CCDS8058.1

UniProtKB/Swiss-Prot

B4DM70, F5H0T1, G3XAD8, P31948, Q3ZCU9, Q5TZU9

UniProtKB/TrEMBL

A8K690, V9HW72

Related

ENSP00000305958.5, ENST00000305218.9

Conserved Domains (2) summary

TIGR00990
Location:7 → 532

3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)

sd00006
Location:364 → 388

TPR; TPR repeat [structural motif]