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    SEC16A SEC16 homolog A, endoplasmic reticulum export factor [ Homo sapiens (human) ]

    Gene ID: 9919, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SEC16Aprovided by HGNC
    Official Full Name
    SEC16 homolog A, endoplasmic reticulum export factorprovided by HGNC
    Primary source
    HGNC:HGNC:29006
    See related
    Ensembl:ENSG00000148396 MIM:612854; AllianceGenome:HGNC:29006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p250; SEC16L; KIAA0310
    Summary
    This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
    Expression
    Ubiquitous expression in stomach (RPKM 11.7), bone marrow (RPKM 11.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEC16A in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136440105..136484740, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148669197..148713859, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139334557..139378235, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29309 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:139310410-139311609 Neighboring gene peptidase, mitochondrial processing subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139330456-139330964 Neighboring gene hESC enhancers GRCh37_chr9:139332501-139333134 to GRCh37_chr9:139333770-139334403 Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:139342099-139343298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:139376640-139377385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139378131-139378875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20524 Neighboring gene chromosome 9 putative open reading frame 163 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:139392592-139393791 Neighboring gene notch receptor 1 Neighboring gene uncharacterized LOC124902310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139420763-139421634 Neighboring gene microRNA 4673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139433302-139433969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139434130-139434814 Neighboring gene Sharpr-MPRA regulatory region 6589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139436183-139436865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20528 Neighboring gene microRNA 4674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells. Watson P, et al. Traffic, 2006 Dec. PMID 17005010, Free PMC Article
    2. Regulation of Sec16 levels and dynamics links proliferation and secretion. Tillmann KD, et al. J Cell Sci, 2015 Feb 15. PMID 25526736
    3. Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes. Christodoulou K, et al. Gut, 2013 Jul. PMID 22543157, Free PMC Article
    4. Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis. Hughes H, et al. J Cell Sci, 2010 Dec 1. PMID 21045114, Free PMC Article
    5. Sec12 binds to Sec16 at transitional ER sites. Montegna EA, et al. PLoS One, 2012. PMID 22347445, Free PMC Article

    See all (205) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
      Title: SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress.
    2. Nbeal2 interacts with Dock7, Sec16a, and Vac14.
      Title: Nbeal2 interacts with Dock7, Sec16a, and Vac14.
    3. these findings highlight a novel function of Sec16A as an essential mediator of endoplasmic reticulum stress-associated unconventional secretion.
      Title: Sec16A is critical for both conventional and unconventional secretion of CFTR.
    4. Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183
      Title: Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.
    5. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion.
      Title: TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.
    6. Results suggest that it is the presence of rare syntenic SEC16A and MAMDC4 deletions that increases susceptibility to axial spondyloarthritis in family members who carry the HLA-B*27 allele.
      Title: Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis.
    7. growth factors modulate Sec16 protein levels and dynamics. Sec16 acts as part of a coherent feed-forward loop, which integrates secretion and growth factor signaling.
      Title: Regulation of Sec16 levels and dynamics links proliferation and secretion.
    8. LRRK2 regulates the anterograde endoplasmic reticulum (ER)-Golgi transport through anchoring Sec16A at the endoplasmic reticulum exit sites (ERES).
      Title: Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
    9. Data show that knockdown of Sec16B but not Sec16A by RNAi affected the morphology of peroxisomes, inhibited the transport of Pex16 from the ER to peroxisomes, and suppressed expression of Pex3.
      Title: Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.
    10. Sec16A remains associated with endoplasmic reticulum exit sites throughout mitosis.
      Title: Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26737, KIAA0310

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein exit from endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of COPII vesicle coating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in substantia nigra development HEP PubMed 
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein transport protein Sec16A
    Names
    protein SEC16 homolog A
    NP_001263347.1
    NP_055681.1
    XP_005266191.1
    XP_011517549.1
    XP_011517551.1
    XP_011517554.1
    XP_011517558.1
    XP_011517559.1
    XP_011517561.1
    XP_011517562.1
    XP_011517564.1
    XP_011517565.1
    XP_047280181.1
    XP_047280182.1
    XP_047280183.1
    XP_047280184.1
    XP_047280185.1
    XP_047280186.1
    XP_047280187.1
    XP_047280188.1
    XP_047280189.1
    XP_047280190.1
    XP_047280191.1
    XP_047280192.1
    XP_047280193.1
    XP_047280194.1
    XP_047280195.1
    XP_047280196.1
    XP_047280197.1
    XP_047280198.1
    XP_047280199.1
    XP_047280200.1
    XP_047280201.1
    XP_047280202.1
    XP_047280203.1
    XP_047280204.1
    XP_047280205.1
    XP_047280206.1
    XP_047280207.1
    XP_047280208.1
    XP_047280209.1
    XP_047280210.1
    XP_047280211.1
    XP_047280212.1
    XP_047280213.1
    XP_047280214.1
    XP_047280215.1
    XP_047280216.1
    XP_047280217.1
    XP_047280218.1
    XP_047280219.1
    XP_047280220.1
    XP_054220341.1
    XP_054220342.1
    XP_054220343.1
    XP_054220344.1
    XP_054220345.1
    XP_054220346.1
    XP_054220347.1
    XP_054220348.1
    XP_054220349.1
    XP_054220350.1
    XP_054220351.1
    XP_054220352.1
    XP_054220353.1
    XP_054220354.1
    XP_054220355.1
    XP_054220356.1
    XP_054220357.1
    XP_054220358.1
    XP_054220359.1
    XP_054220360.1
    XP_054220361.1
    XP_054220362.1
    XP_054220363.1
    XP_054220364.1
    XP_054220365.1
    XP_054220366.1
    XP_054220367.1
    XP_054220368.1
    XP_054220369.1
    XP_054220370.1
    XP_054220371.1
    XP_054220372.1
    XP_054220373.1
    XP_054220374.1
    XP_054220375.1
    XP_054220376.1
    XP_054220377.1
    XP_054220378.1
    XP_054220379.1
    XP_054220380.1
    XP_054220381.1
    XP_054220382.1
    XP_054220383.1
    XP_054220384.1
    XP_054220385.1
    XP_054220386.1
    XP_054220387.1
    XP_054220388.1
    XP_054220389.1
    XP_054220390.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276418.2 → NP_001263347.1  protein transport protein Sec16A isoform 2

      See identical proteins and their annotated locations for NP_001263347.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AB002308, AB593115, AL592301, BC070488
      Consensus CDS
      CCDS75936.1
      UniProtKB/TrEMBL
      A0A3F2YNX0, F1T0I1
      Related
      ENSP00000290037.7, ENST00000290037.10
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    2. NM_014866.2 → NP_055681.1  protein transport protein Sec16A isoform 1

      See identical proteins and their annotated locations for NP_055681.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB002308, BM975558
      Consensus CDS
      CCDS55351.1
      UniProtKB/Swiss-Prot
      A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Related
      ENSP00000508822.1, ENST00000684901.1
      Conserved Domains (2) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl26464
      Location:4 → 298
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      136440105..136484740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424252.1 → XP_047280208.1  protein transport protein Sec16A isoform X27

      UniProtKB/TrEMBL
      A0A3F2YNX0

    2. XM_047424250.1 → XP_047280206.1  protein transport protein Sec16A isoform X26

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    3. XM_047424248.1 → XP_047280204.1  protein transport protein Sec16A isoform X24

      UniProtKB/TrEMBL
      A0A8I5KPG1, A4QN19, E7ESY3

    4. XM_047424244.1 → XP_047280200.1  protein transport protein Sec16A isoform X21

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    5. XM_047424246.1 → XP_047280202.1  protein transport protein Sec16A isoform X23

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    6. XM_047424249.1 → XP_047280205.1  protein transport protein Sec16A isoform X25

      UniProtKB/TrEMBL
      A0A3F2YNX0

    7. XM_047424245.1 → XP_047280201.1  protein transport protein Sec16A isoform X22

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    8. XM_047424243.1 → XP_047280199.1  protein transport protein Sec16A isoform X20

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    9. XM_047424242.1 → XP_047280198.1  protein transport protein Sec16A isoform X19

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    10. XM_047424240.1 → XP_047280196.1  protein transport protein Sec16A isoform X17

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    11. XM_047424236.1 → XP_047280192.1  protein transport protein Sec16A isoform X13

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    12. XM_047424239.1 → XP_047280195.1  protein transport protein Sec16A isoform X16

      UniProtKB/TrEMBL
      A0A3F2YNX0

    13. XM_047424241.1 → XP_047280197.1  protein transport protein Sec16A isoform X18

      UniProtKB/TrEMBL
      A0A3F2YNX0

    14. XM_047424235.1 → XP_047280191.1  protein transport protein Sec16A isoform X12

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    15. XM_047424233.1 → XP_047280189.1  protein transport protein Sec16A isoform X10

      UniProtKB/TrEMBL
      A0A3F2YNX0

    16. XM_047424237.1 → XP_047280193.1  protein transport protein Sec16A isoform X14

      UniProtKB/TrEMBL
      A0A3F2YNX0

    17. XM_047424229.1 → XP_047280185.1  protein transport protein Sec16A isoform X6

      UniProtKB/Swiss-Prot
      A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
      UniProtKB/TrEMBL
      A0A3F2YNZ0

    18. XM_047424232.1 → XP_047280188.1  protein transport protein Sec16A isoform X9

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    19. XM_047424225.1 → XP_047280181.1  protein transport protein Sec16A isoform X2

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    20. XM_047424227.1 → XP_047280183.1  protein transport protein Sec16A isoform X4

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    21. XM_047424234.1 → XP_047280190.1  protein transport protein Sec16A isoform X11

      UniProtKB/TrEMBL
      A0A3F2YNX0, F1T0I1

    22. XM_047424238.1 → XP_047280194.1  protein transport protein Sec16A isoform X15

      UniProtKB/TrEMBL
      A0A3F2YNX0

    23. XM_047424231.1 → XP_047280187.1  protein transport protein Sec16A isoform X8

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    24. XM_047424228.1 → XP_047280184.1  protein transport protein Sec16A isoform X5

      UniProtKB/TrEMBL
      A0A3F2YNX0

    25. XM_047424230.1 → XP_047280186.1  protein transport protein Sec16A isoform X7

      UniProtKB/TrEMBL
      A0A3F2YNX0

    26. XM_011519260.3 → XP_011517562.1  protein transport protein Sec16A isoform X1

      See identical proteins and their annotated locations for XP_011517562.1

      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    27. XM_047424226.1 → XP_047280182.1  protein transport protein Sec16A isoform X3

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    28. XM_011519247.3 → XP_011517549.1  protein transport protein Sec16A isoform X1

      See identical proteins and their annotated locations for XP_011517549.1

      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    29. XM_047424264.1 → XP_047280220.1  protein transport protein Sec16A isoform X31

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    30. XM_047424261.1 → XP_047280217.1  protein transport protein Sec16A isoform X29

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    31. XM_047424263.1 → XP_047280219.1  protein transport protein Sec16A isoform X27

      UniProtKB/TrEMBL
      A0A3F2YNX0

    32. XM_047424260.1 → XP_047280216.1  protein transport protein Sec16A isoform X26

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    33. XM_011519263.2 → XP_011517565.1  protein transport protein Sec16A isoform X24

      UniProtKB/TrEMBL
      A0A8I5KPG1, A4QN19, E7ESY3
      Related
      ENSP00000508778.1, ENST00000690691.1
      Conserved Domains (1) summary
      cd09233
      Location:1260 → 1622
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    34. XM_047424256.1 → XP_047280212.1  protein transport protein Sec16A isoform X21

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    35. XM_047424258.1 → XP_047280214.1  protein transport protein Sec16A isoform X23

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    36. XM_047424262.1 → XP_047280218.1  protein transport protein Sec16A isoform X30

      UniProtKB/TrEMBL
      A0A3F2YNX0

    37. XM_047424254.1 → XP_047280210.1  protein transport protein Sec16A isoform X28

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    38. XM_047424259.1 → XP_047280215.1  protein transport protein Sec16A isoform X25

      UniProtKB/TrEMBL
      A0A3F2YNX0

    39. XM_047424257.1 → XP_047280213.1  protein transport protein Sec16A isoform X22

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    40. XM_047424255.1 → XP_047280211.1  protein transport protein Sec16A isoform X20

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    41. XM_011519262.2 → XP_011517564.1  protein transport protein Sec16A isoform X19

      UniProtKB/TrEMBL
      A4QN19, E7ESY3
      Conserved Domains (2) summary
      cd09233
      Location:1260 → 1622
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      PHA03247
      Location:4 → 298
      PHA03247; large tegument protein UL36; Provisional

    42. XM_047424253.1 → XP_047280209.1  protein transport protein Sec16A isoform X17

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    43. XM_011519259.3 → XP_011517561.1  protein transport protein Sec16A isoform X16

      UniProtKB/TrEMBL
      A0A3F2YNX0
      Related
      ENSP00000360771.4, ENST00000371706.8
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    44. XM_011519257.2 → XP_011517559.1  protein transport protein Sec16A isoform X12

      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Related
      ENSP00000387583.2, ENST00000431893.3
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    45. XM_047424251.1 → XP_047280207.1  protein transport protein Sec16A isoform X14

      UniProtKB/TrEMBL
      A0A3F2YNX0

    46. XM_011519252.2 → XP_011517554.1  protein transport protein Sec16A isoform X6

      See identical proteins and their annotated locations for XP_011517554.1

      UniProtKB/Swiss-Prot
      A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Related
      ENSP00000325827.7, ENST00000313050.11
      Conserved Domains (2) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
      cl26464
      Location:4 → 298
      Atrophin-1; Atrophin-1 family

    47. XM_047424247.1 → XP_047280203.1  protein transport protein Sec16A isoform X9

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    48. XM_011519249.2 → XP_011517551.1  protein transport protein Sec16A isoform X2

      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    49. XM_011519256.2 → XP_011517558.1  protein transport protein Sec16A isoform X11

      See identical proteins and their annotated locations for XP_011517558.1

      UniProtKB/TrEMBL
      A0A3F2YNX0, F1T0I1
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    50. XM_005266134.3 → XP_005266191.1  protein transport protein Sec16A isoform X1

      See identical proteins and their annotated locations for XP_005266191.1

      UniProtKB/TrEMBL
      A0A3F2YNZ0
      Conserved Domains (1) summary
      cd09233
      Location:1497 → 1859
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      148669197..148713859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364400.1 → XP_054220375.1  protein transport protein Sec16A isoform X57

      UniProtKB/TrEMBL
      A0A3F2YNX0

    2. XM_054364395.1 → XP_054220370.1  protein transport protein Sec16A isoform X56

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    3. XM_054364393.1 → XP_054220368.1  protein transport protein Sec16A isoform X54

      UniProtKB/TrEMBL
      A0A3F2YNX0

    4. XM_054364387.1 → XP_054220362.1  protein transport protein Sec16A isoform X51

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    5. XM_054364390.1 → XP_054220365.1  protein transport protein Sec16A isoform X53

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    6. XM_054364394.1 → XP_054220369.1  protein transport protein Sec16A isoform X55

      UniProtKB/TrEMBL
      A0A3F2YNX0

    7. XM_054364388.1 → XP_054220363.1  protein transport protein Sec16A isoform X52

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    8. XM_054364386.1 → XP_054220361.1  protein transport protein Sec16A isoform X50

      UniProtKB/TrEMBL
      A0A3F2YNX0

    9. XM_054364384.1 → XP_054220359.1  protein transport protein Sec16A isoform X49

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    10. XM_054364381.1 → XP_054220356.1  protein transport protein Sec16A isoform X47

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    11. XM_054364377.1 → XP_054220352.1  protein transport protein Sec16A isoform X43

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    12. XM_054364380.1 → XP_054220355.1  protein transport protein Sec16A isoform X46

      UniProtKB/TrEMBL
      A0A3F2YNX0

    13. XM_054364382.1 → XP_054220357.1  protein transport protein Sec16A isoform X48

      UniProtKB/TrEMBL
      A0A3F2YNX0

    14. XM_054364376.1 → XP_054220351.1  protein transport protein Sec16A isoform X42

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    15. XM_054364374.1 → XP_054220349.1  protein transport protein Sec16A isoform X40

      UniProtKB/TrEMBL
      A0A3F2YNX0

    16. XM_054364378.1 → XP_054220353.1  protein transport protein Sec16A isoform X44

      UniProtKB/TrEMBL
      A0A3F2YNX0

    17. XM_054364371.1 → XP_054220346.1  protein transport protein Sec16A isoform X37

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    18. XM_054364373.1 → XP_054220348.1  protein transport protein Sec16A isoform X39

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    19. XM_054364367.1 → XP_054220342.1  protein transport protein Sec16A isoform X33

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    20. XM_054364369.1 → XP_054220344.1  protein transport protein Sec16A isoform X35

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    21. XM_054364375.1 → XP_054220350.1  protein transport protein Sec16A isoform X41

      UniProtKB/TrEMBL
      A0A3F2YNX0

    22. XM_054364379.1 → XP_054220354.1  protein transport protein Sec16A isoform X45

      UniProtKB/TrEMBL
      A0A3F2YNX0

    23. XM_054364370.1 → XP_054220345.1  protein transport protein Sec16A isoform X36

      UniProtKB/TrEMBL
      A0A3F2YNX0

    24. XM_054364372.1 → XP_054220347.1  protein transport protein Sec16A isoform X38

      UniProtKB/TrEMBL
      A0A3F2YNX0

    25. XM_054364366.1 → XP_054220341.1  protein transport protein Sec16A isoform X32

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    26. XM_054364368.1 → XP_054220343.1  protein transport protein Sec16A isoform X34

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    27. XM_054364389.1 → XP_054220364.1  protein transport protein Sec16A isoform X1

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    28. XM_054364401.1 → XP_054220376.1  protein transport protein Sec16A isoform X16

      UniProtKB/TrEMBL
      A0A3F2YNX0

    29. XM_054364396.1 → XP_054220371.1  protein transport protein Sec16A isoform X11

      UniProtKB/TrEMBL
      A0A3F2YNX0, F1T0I1

    30. XM_054364402.1 → XP_054220377.1  protein transport protein Sec16A isoform X17

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    31. XM_054364399.1 → XP_054220374.1  protein transport protein Sec16A isoform X13

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    32. XM_054364398.1 → XP_054220373.1  protein transport protein Sec16A isoform X12

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    33. XM_054364397.1 → XP_054220372.1  protein transport protein Sec16A isoform X14

      UniProtKB/TrEMBL
      A0A3F2YNX0

    34. XM_054364391.1 → XP_054220366.1  protein transport protein Sec16A isoform X6

      UniProtKB/Swiss-Prot
      A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
      UniProtKB/TrEMBL
      A0A3F2YNZ0

    35. XM_054364392.1 → XP_054220367.1  protein transport protein Sec16A isoform X9

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    36. XM_054364385.1 → XP_054220360.1  protein transport protein Sec16A isoform X2

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    37. XM_054364383.1 → XP_054220358.1  protein transport protein Sec16A isoform X1

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    38. XM_054364406.1 → XP_054220381.1  protein transport protein Sec16A isoform X21

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    39. XM_054364411.1 → XP_054220386.1  protein transport protein Sec16A isoform X26

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    40. XM_054364409.1 → XP_054220384.1  protein transport protein Sec16A isoform X24

      UniProtKB/TrEMBL
      A0A8I5KPG1, A4QN19, E7ESY3

    41. XM_054364415.1 → XP_054220390.1  protein transport protein Sec16A isoform X31

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    42. XM_054364412.1 → XP_054220387.1  protein transport protein Sec16A isoform X29

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    43. XM_054364414.1 → XP_054220389.1  protein transport protein Sec16A isoform X27

      UniProtKB/TrEMBL
      A0A3F2YNX0

    44. XM_054364408.1 → XP_054220383.1  protein transport protein Sec16A isoform X23

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    45. XM_054364413.1 → XP_054220388.1  protein transport protein Sec16A isoform X30

      UniProtKB/TrEMBL
      A0A3F2YNX0

    46. XM_054364404.1 → XP_054220379.1  protein transport protein Sec16A isoform X28

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    47. XM_054364410.1 → XP_054220385.1  protein transport protein Sec16A isoform X25

      UniProtKB/TrEMBL
      A0A3F2YNX0

    48. XM_054364407.1 → XP_054220382.1  protein transport protein Sec16A isoform X22

      UniProtKB/TrEMBL
      A0A3F2YNZ0

    49. XM_054364405.1 → XP_054220380.1  protein transport protein Sec16A isoform X20

      UniProtKB/TrEMBL
      A4QN19, E7ESY3

    50. XM_054364403.1 → XP_054220378.1  protein transport protein Sec16A isoform X19

      UniProtKB/TrEMBL
      A4QN19, E7ESY3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15027.4 GenPept UniProtKB/Swiss-Prot:O15027

    Gene LinkOut

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