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    SNORA14B small nucleolar RNA, H/ACA box 14B [ Homo sapiens (human) ]

    Gene ID: 677802, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SNORA14Bprovided by HGNC
    Official Full Name
    small nucleolar RNA, H/ACA box 14Bprovided by HGNC
    Primary source
    HGNC:HGNC:32603
    See related
    Ensembl:ENSG00000207181 AllianceGenome:HGNC:32603
    Gene type
    snoRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACA14b
    Summary
    Small nucleolar RNAs (snoRNAs) are 60-150 nt long non-coding RNAs, and include two groups: C/D box snoRNAs and H/ACA box snoRNAs. The C/D box snoRNAs are guides for the 2'-O-ribose methylation of rRNAs or snRNAs. The H/ACA box snoRNAs are guides for the isomerization of uridine residues into pseudouridine. This gene belongs to the group of the H/ACA box snoRNAs, and functions in 18S rRNA pseudouridylation at position U966. The gene duplication generates a 91% identical copy on chromosome 7. [provided by RefSeq, Oct 2008]
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    Genomic context

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    See SNORA14B in Genome Data Viewer
    Location:
    1q42.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (235127803..235127937, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (234519519..234519653, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (235291118..235291252, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:235115282-235115785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:235122747-235123286 and GRCh37_chr1:235122207-235122746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:235123287-235123826 Neighboring gene long intergenic non-protein coding RNA 3108 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:235133684-235134883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2780 Neighboring gene Sharpr-MPRA regulatory region 4658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2786 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2788 Neighboring gene Sharpr-MPRA regulatory region 5019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2789 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:235191005-235191504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2790 Neighboring gene long intergenic non-protein coding RNA 1348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:235245875-235246397 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:235256647-235257230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2792 Neighboring gene uncharacterized LOC105379283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2793 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2794 Neighboring gene translocase of outer mitochondrial membrane 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:235322928-235323532 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:235323819-235325018 Neighboring gene RNA binding motif protein 34 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:235334884-235335090 Neighboring gene AT-rich interaction domain 4B Neighboring gene microRNA 4753

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Lestrade L, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381836, Free PMC Article
    2. Human box H/ACA pseudouridylation guide RNA machinery. Kiss AM, et al. Mol Cell Biol, 2004 Jul. PMID 15199136, Free PMC Article
    3. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. Dieci G, et al. Genomics, 2009 Aug. PMID 19446021

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • ACA14b snoRNA

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002956.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AJ609457
      Related
      ENST00000384452.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      235127803..235127937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      234519519..234519653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials