Foxi3 forkhead box I3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Foxi3provided by MGI
Official Full Name: forkhead box I3provided by MGI
Primary source: MGI:MGI:3511278
See related: Ensembl:ENSMUSG00000055874 AllianceGenome:MGI:3511278
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including otic placode development; parathyroid gland development; and pharyngeal system development. Is active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; exocrine system; integumental system; and sensory organ. Used to study Goldenhar syndrome. Orthologous to human FOXI3 (forkhead box I3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (70933590..70938050)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (70956606..70961066)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency.
Title: Identification of potential molecular mechanism related to craniofacial dysmorphism caused by FOXI3 deficiency.
The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.
Title: The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.
FOXI3 pathogenic variants cause one form of craniofacial microsomia.
Title: FOXI3 pathogenic variants cause one form of craniofacial microsomia.
Study discovered that Tbx1 and Foxi3 factors interact at minimum, in the third pharyngeal pouch endoderm, needed to form the thymus and parathyroid glands. Iinactivation of Foxi3 results in cardiovascular anomalies. Global inactivation of Tbx1 and Foxi3 both result in failure of the epithelia to properly invaginate along with an expansion of multilayers of pharyngeal endoderm cells.
Title: Tbx1 and Foxi3 genetically interact in the pharyngeal pouch endoderm in a mouse model for 22q11.2 deletion syndrome.
Foxi3 regulates multiple aspects of hair follicle development and homeostasis.
Title: Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.
Foxi3 regulates specification of hair follicle stem cell in embryogenesis, and is essential for hair follicle activation during hair regeneration.
Title: Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification and Activation.
Foxi3 is necessary to prime pre-placodal ectoderm for the correct interpretation of inductive signals for the otic and epibranchial placodes.
Title: The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.
Foxi3 maintains dental epithelial cells in an undifferentiated state and thereby regulates multiple stages of tooth morphogenesis.
Title: Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning.
Data indicate that Foxi3 mutants succumb to apoptosis from embryonic day 9.75 onwards, and this cell death correlates with a delay in expression of Fgf8 in branchial arch ectoderm.
Title: Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers.
Eda and activin A are upstream regulators of Foxi3 in skin appendage placodes
Title: Expression of Foxi3 is regulated by ectodysplasin in skin appendage placodes.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

Foxi3 (e-PCR), detects polymorphism
- UniSTS:471074

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis of dentin-containing tooth	ISS Inferred from Sequence or Structural Similarity more info
involved_in otic placode development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in parathyroid gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in thymus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: forkhead box protein I3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.