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    Coa8 cytochrome c oxidase assembly factor 8 [ Mus musculus (house mouse) ]

    Gene ID: 68020, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coa8provided by MGI
    Official Full Name
    cytochrome c oxidase assembly factor 8provided by MGI
    Primary source
    MGI:MGI:1915270
    See related
    Ensembl:ENSMUSG00000037787 AllianceGenome:MGI:1915270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apop1; Apop-1; Apopt1; 1700081D05Rik; 2810002N01Rik
    Summary
    Involved in several processes, including mitochondrial cytochrome c oxidase assembly; positive regulation of cytochrome-c oxidase activity; and protein stabilization. Acts upstream of or within intrinsic apoptotic signaling pathway. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 17. Orthologous to human COA8 (cytochrome c oxidase assembly factor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 50.8), duodenum adult (RPKM 14.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Coa8 in Genome Data Viewer
    Location:
    12 F1; 12 61.11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111679394..111721491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111713268..111755057)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635 Neighboring gene BCL2-associated athanogene 5 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS. Signes A, et al. EMBO Mol Med, 2019 Jan. PMID 30552096, Free PMC Article
    2. Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. Yasuda O, et al. J Biol Chem, 2006 Aug 18. PMID 16782708
    3. Akt activation prevents Apop-1-induced death of cells. Sun X, et al. Biochem Biophys Res Commun, 2008 Dec 26. PMID 18977203
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of reactive oxygen species biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytochrome-c oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytochrome-c oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to reactive oxygen species IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in matrix side of mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in matrix side of mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase assembly factor 8
    Names
    UPF0671 protein C14orf153 homolog
    apoptogenic protein 1, mitochondrial
    apoptogenic, mitochondrial 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163388.1 → NP_001156860.1  cytochrome c oxidase assembly factor 8 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC152065, AK002873, AK012648
      Consensus CDS
      CCDS49181.1
      UniProtKB/TrEMBL
      Q8CDX7
      Related
      ENSMUSP00000131169.3, ENSMUST00000163220.10
      Conserved Domains (1) summary
      pfam10231
      Location:55 → 160
      DUF2315; Uncharacterized conserved protein (DUF2315)

    2. NM_026511.2 → NP_080787.1  cytochrome c oxidase assembly factor 8 isoform 2

      See identical proteins and their annotated locations for NP_080787.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK002873, AK012648, BY392793
      Consensus CDS
      CCDS26186.1
      UniProtKB/Swiss-Prot
      Q9CQW7
      UniProtKB/TrEMBL
      Q8CDX7
      Related
      ENSMUSP00000038865.6, ENSMUST00000040519.12
      Conserved Domains (1) summary
      pfam10231
      Location:55 → 182
      DUF2315; Uncharacterized conserved protein (DUF2315)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111679394..111721491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516179.5 → XP_006516242.1  cytochrome c oxidase assembly factor 8 isoform X2

      UniProtKB/TrEMBL
      Q8CDX7
      Conserved Domains (1) summary
      pfam10231
      Location:55 → 160
      DUF2315; Uncharacterized conserved protein (DUF2315)

    2. XM_006516178.5 → XP_006516241.1  cytochrome c oxidase assembly factor 8 isoform X1

      UniProtKB/TrEMBL
      Q8CDX7
      Conserved Domains (1) summary
      pfam10231
      Location:55 → 160
      DUF2315; Uncharacterized conserved protein (DUF2315)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQW7.1 GenPept UniProtKB/Swiss-Prot:Q9CQW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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