Dnajc1 DnaJ heat shock protein family (Hsp40) member C1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajc1provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member C1provided by MGI
Primary source: MGI:MGI:103268
See related: Ensembl:ENSMUSG00000026740 AllianceGenome:MGI:103268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MTJ1; ERdj1; ERj1p; Dnajl1; 4733401K02Rik; D230036H06Rik
Summary: Enables protein-folding chaperone binding activity. Acts upstream of or within protein folding and regulation of translation. Located in endoplasmic reticulum and plasma membrane. Orthologous to human DNAJC1 (DnaJ heat shock protein family (Hsp40) member C1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 10.4), thymus adult (RPKM 9.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 12.89 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (18210445..18402025, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (18205634..18394099, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that vaspin is a ligand for cell-surface GRP78 (glucose-regulated protein 78kD)/MTJ-1 complex; subsequent signal transduction exerts beneficial effects on endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity.
Title: Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex.
plasma membrane-associated GRP78 is coupled to pertussis toxin-insensitive Galphaq11 and forms a ternary signaling complex with MTJ-1
Title: Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages.
ERj1p inhibits translation in the absence of BiP, and mediates binding of the nuclear import factor importin beta and import into the nucleus.
Title: ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum.
ERj1p coordinates the ribosome at the membrane and allosteric effects may mediate ERj1p's regulatory activity
Title: ERj1p uses a universal ribosomal adaptor site to coordinate the 80S ribosome at the membrane.
In addition to assisting the chaperone GRP78 in protein quality control in the endoplasmic reticulum, MTJ-1 is essential for transport of GRP78 to the macrophage surface, which serves a number of functions in immune regulation and signal transduction.
Title: The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling.
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment
Title: BIP co-chaperone MTJ1/ERDJ1 interacts with inter-alpha-trypsin inhibitor heavy chain 4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IDA Inferred from Direct Assay more info	PubMed
enables ribosome binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein folding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of translation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dnaJ homolog subfamily C member 1

Names: DnaJ (Hsp40) homolog, subfamily C, member 1; DnaJ-like protein 1; dnaJ protein homolog MTJ1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190817.2 → NP_001177746.1 dnaJ homolog subfamily C member 1 precursor

See identical proteins and their annotated locations for NP_001177746.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL845265, AL928557, AL928620

Consensus CDS

CCDS15709.1

UniProtKB/Swiss-Prot

Q61712

Related

ENSMUSP00000088980.6, ENSMUST00000091418.12

Conserved Domains (3) summary

smart00717
Location:493 → 542

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:494 → 541

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00226
Location:61 → 122

DnaJ; DnaJ domain
NM_007869.4 → NP_031895.1 dnaJ homolog subfamily C member 1 precursor

See identical proteins and their annotated locations for NP_031895.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL845265, AL928557, AL928620

Consensus CDS

CCDS15709.1

UniProtKB/Swiss-Prot

Q61712

Related

ENSMUSP00000126321.2, ENSMUST00000166495.8

Conserved Domains (3) summary

smart00717
Location:493 → 542

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:494 → 541

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam00226
Location:61 → 122

DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

18210445..18402025 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238947.3 → XP_011237249.1 dnaJ homolog subfamily C member 1 isoform X1

Conserved Domains (2) summary

cd00167
Location:244 → 291

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cl30717
Location:103 → 243

InfB; Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]