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    Pira2 paired-Ig-like receptor A2 [ Mus musculus (house mouse) ]

    Gene ID: 18725, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pira2provided by MGI
    Official Full Name
    paired-Ig-like receptor A2provided by MGI
    Primary source
    MGI:MGI:1195970
    See related
    Ensembl:ENSMUSG00000089942 AllianceGenome:MGI:1195970
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6M23
    Summary
    Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRA6 (leukocyte immunoglobulin like receptor A6); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 17.0), mammary gland adult (RPKM 8.6) and 13 other tissues See more
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    Genomic context

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    See Pira2 in Genome Data Viewer
    Location:
    7 A1; 7 2.21 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3839807..3848102, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3836808..3845104, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene paired-Ig-like receptor A2, pseudogene 1 Neighboring gene paired-Ig-like receptor A13 Neighboring gene STARR-positive B cell enhancer mm9_chr7:3796869-3797170 Neighboring gene predicted pseudogene 10693 Neighboring gene paired-Ig-like receptor A12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Kubagawa H, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144225, Free PMC Article
    2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables IgM binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inhibitory MHC class I receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Fc-epsilon receptor I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    paired-Ig-like receptor A2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379689.1 → NP_001366618.1  paired-Ig-like receptor A2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC161409
      UniProtKB/TrEMBL
      A2NTJ9
      Conserved Domains (3) summary
      cd00096
      Location:123 → 127
      Ig; Ig strand A [structural motif]
      cd16843
      Location:224 → 313
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:122 → 218
      Ig; Immunoglobulin domain

    2. NM_011089.2 → NP_035219.2  paired-Ig-like receptor A2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_035219.2

      Status: VALIDATED

      Source sequence(s)
      AC161409, AK140776
      Consensus CDS
      CCDS39731.1
      UniProtKB/TrEMBL
      A2NTJ9, F8VQ94
      Related
      ENSMUSP00000104255.4, ENSMUST00000108615.10
      Conserved Domains (2) summary
      smart00410
      Location:529 → 617
      IG_like; Immunoglobulin like
      cl11960
      Location:225 → 315
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3839807..3848102 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539625.3 → XP_006539688.1  paired-Ig-like receptor A2 isoform X6

      UniProtKB/TrEMBL
      A2NTJ9
      Conserved Domains (1) summary
      cl11960
      Location:130 → 220
      Ig; Immunoglobulin domain

    2. XM_036152785.1 → XP_036008678.1  paired-Ig-like receptor A2 isoform X5

      UniProtKB/TrEMBL
      D3Z3W9, O70434
      Related
      ENSMUSP00000113857.2, ENSMUST00000119469.2
      Conserved Domains (3) summary
      cd00096
      Location:124 → 128
      Ig; Ig strand A [structural motif]
      cd16843
      Location:225 → 314
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:123 → 219
      Ig; Immunoglobulin domain

    3. XM_036152782.1 → XP_036008675.1  paired-Ig-like receptor A2 isoform X2

      UniProtKB/TrEMBL
      A2NTJ9
      Conserved Domains (3) summary
      cd00096
      Location:129 → 133
      Ig; Ig strand A [structural motif]
      cd16843
      Location:230 → 319
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:128 → 224
      Ig; Immunoglobulin domain

    4. XM_036152783.1 → XP_036008676.1  paired-Ig-like receptor A2 isoform X3

      UniProtKB/TrEMBL
      A2NTJ9
      Conserved Domains (3) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cd16843
      Location:231 → 320
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:129 → 225
      Ig; Immunoglobulin domain

    5. XM_036152784.1 → XP_036008677.1  paired-Ig-like receptor A2 isoform X4

      UniProtKB/TrEMBL
      O70434
      Conserved Domains (3) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cd16843
      Location:231 → 320
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:129 → 225
      Ig; Immunoglobulin domain

    6. XM_036152781.1 → XP_036008674.1  paired-Ig-like receptor A2 isoform X1

      UniProtKB/TrEMBL
      A2NTJ9
      Conserved Domains (3) summary
      cd00096
      Location:130 → 134
      Ig; Ig strand A [structural motif]
      cd16843
      Location:231 → 320
      IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
      cl11960
      Location:129 → 225
      Ig; Immunoglobulin domain

    RNA

    1. XR_004934041.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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