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    Ikzf4 IKAROS family zinc finger 4 [ Mus musculus (house mouse) ]

    Gene ID: 22781, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ikzf4provided by MGI
    Official Full Name
    IKAROS family zinc finger 4provided by MGI
    Primary source
    MGI:MGI:1343139
    See related
    Ensembl:ENSMUSG00000002578 AllianceGenome:MGI:1343139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eos; Zfpn1a4; Znfn1a4; A630026H08Rik
    Summary
    Enables bHLH transcription factor binding activity and sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear body. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; hemolymphoid system; and retina. Used to study encephalomyelitis. Orthologous to human IKZF4 (IKAROS family zinc finger 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 4.1), CNS E14 (RPKM 4.1) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ikzf4 in Genome Data Viewer
    Location:
    10 D3; 10 77.11 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128466708..128505668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128630839..128669671, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5200 Neighboring gene predicted gene 9182 Neighboring gene STARR-positive B cell enhancer ABC_E904 Neighboring gene ribosomal protein S26 Neighboring gene predicted gene, 26876 Neighboring gene predicted gene, 51824 Neighboring gene STARR-positive B cell enhancer ABC_E2343 Neighboring gene sulfite oxidase Neighboring gene ribosomal protein L12 pseudogene Neighboring gene RAB5B, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables bHLH transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger protein Eos
    Names
    ikaros family zinc finger protein 4
    zinc finger protein, subfamily 1A, 4 (Eos)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358536.2NP_001345465.1  zinc finger protein Eos isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform 2.
      Source sequence(s)
      AC117232
      Conserved Domains (3) summary
      COG5189
      Location:156216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:106126
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:146171
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001358537.2NP_001345466.1  zinc finger protein Eos isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117232
      Conserved Domains (3) summary
      COG5189
      Location:156216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:106126
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:146171
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001428880.1NP_001415809.1  zinc finger protein Eos isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 5, encodes isoform 3.
      Source sequence(s)
      AC117232
    4. NM_001428881.1NP_001415810.1  zinc finger protein Eos isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117232
    5. NM_001428882.1NP_001415811.1  zinc finger protein Eos isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform 4.
      Source sequence(s)
      AC117232
      UniProtKB/TrEMBL
      A0A571BEH5
    6. NM_001428883.1NP_001415812.1  zinc finger protein Eos isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117232
      UniProtKB/TrEMBL
      A0A571BEH5
    7. NM_001428884.1NP_001415813.1  zinc finger protein Eos isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117232
    8. NM_011772.4NP_035902.2  zinc finger protein Eos isoform 1

      See identical proteins and their annotated locations for NP_035902.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC117232
      Consensus CDS
      CCDS24284.2
      UniProtKB/Swiss-Prot
      B9EJ21, Q3TCZ7, Q8C208, Q9Z2Z2
      Related
      ENSMUSP00000114404.2, ENSMUST00000133342.10
      Conserved Domains (2) summary
      sd00017
      Location:161181
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:201226
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128466708..128505668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155766.1XP_036011659.1  zinc finger protein Eos isoform X1

      Conserved Domains (3) summary
      COG5189
      Location:208268
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:158178
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:198223
      zf-H2C2_2; Zinc-finger double domain
    2. XM_006513612.2XP_006513675.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain
    3. XM_030245075.1XP_030100935.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011243440.1XP_011241742.1  zinc finger protein Eos isoform X2

      See identical proteins and their annotated locations for XP_011241742.1

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain
    5. XM_006513613.5XP_006513676.1  zinc finger protein Eos isoform X3

      Related
      ENSMUSP00000158702.2, ENSMUST00000238610.2
      Conserved Domains (3) summary
      COG5189
      Location:164224
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:114134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154179
      zf-H2C2_2; Zinc-finger double domain
    6. XM_030245076.2XP_030100936.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain
    7. XM_011243441.4XP_011241743.1  zinc finger protein Eos isoform X3

      Related
      ENSMUSP00000158614.2, ENSMUST00000238712.2
      Conserved Domains (3) summary
      COG5189
      Location:164224
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:114134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154179
      zf-H2C2_2; Zinc-finger double domain
    8. XM_030245077.2XP_030100937.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain
    9. XM_036155767.1XP_036011660.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain
    10. XM_036155768.1XP_036011661.1  zinc finger protein Eos isoform X3

      UniProtKB/TrEMBL
      A0A571BEH5
      Conserved Domains (3) summary
      COG5189
      Location:164224
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:114134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154179
      zf-H2C2_2; Zinc-finger double domain
    11. XM_006513616.4XP_006513679.1  zinc finger protein Eos isoform X5

      Conserved Domains (3) summary
      COG5189
      Location:109169
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:5979
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:99124
      zf-H2C2_2; Zinc-finger double domain
    12. XM_030245078.2XP_030100938.1  zinc finger protein Eos isoform X4

      Related
      ENSMUSP00000152234.2, ENSMUST00000222067.2
      Conserved Domains (3) summary
      COG5189
      Location:156216
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:106126
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:146171
      zf-H2C2_2; Zinc-finger double domain
    13. XM_030245074.2XP_030100934.1  zinc finger protein Eos isoform X2

      Conserved Domains (3) summary
      COG5189
      Location:166226
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:116136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:156181
      zf-H2C2_2; Zinc-finger double domain