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    Psmc5 protease (prosome, macropain) 26S subunit, ATPase 5 [ Mus musculus (house mouse) ]

    Gene ID: 19184, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psmc5provided by MGI
    Official Full Name
    protease (prosome, macropain) 26S subunit, ATPase 5provided by MGI
    Primary source
    MGI:MGI:105047
    See related
    Ensembl:ENSMUSG00000020708 AllianceGenome:MGI:105047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpt6; mSUG1
    Summary
    Enables signaling receptor binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Part of proteasome regulatory particle. Is expressed in several structures, including gonad; hemolymphoid system gland; limb; liver; and lung. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 94.4), cerebellum adult (RPKM 79.6) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Psmc5 in Genome Data Viewer
    Location:
    11 E1; 11 68.89 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106147011..106153938)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106256185..106263112)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 47 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106078089-106078198 Neighboring gene DEAD box helicase 42 Neighboring gene STARR-positive B cell enhancer ABC_E7080 Neighboring gene STARR-positive B cell enhancer ABC_E5286 Neighboring gene STARR-positive B cell enhancer ABC_E597 Neighboring gene FtsJ RNA 2'-O-methyltransferase 3 Neighboring gene predicted gene, 23645 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106130475-106130662 Neighboring gene SWI/SNF related BAF chromatin remodeling complex subunit D2 Neighboring gene STARR-positive B cell enhancer ABC_E598 Neighboring gene STARR-positive B cell enhancer ABC_E3029 Neighboring gene testicular cell adhesion molecule 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables general transcription initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables general transcription initiation factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thyrotropin-releasing hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thyrotropin-releasing hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription factor binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome accessory complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    26S proteasome regulatory subunit 8
    Names
    26S protease regulatory subunit 8
    26S proteasome AAA-ATPase subunit RPT6
    p45/SUG
    proteasome 26S subunit ATPase 5
    proteasome subunit p45

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008950.1NP_032976.1  26S proteasome regulatory subunit 8

      See identical proteins and their annotated locations for NP_032976.1

      Status: PROVISIONAL

      Source sequence(s)
      Z54219
      Consensus CDS
      CCDS25553.1
      UniProtKB/Swiss-Prot
      P62196, Q3UL51, Q9CWN5
      Related
      ENSMUSP00000021049.3, ENSMUST00000021049.9
      Conserved Domains (1) summary
      COG1222
      Location:4404
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      106147011..106153938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)