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    Otub2 OTU domain, ubiquitin aldehyde binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 68149, updated on 9-Dec-2024

    Summary

    Official Symbol
    Otub2provided by MGI
    Official Full Name
    OTU domain, ubiquitin aldehyde binding 2provided by MGI
    Primary source
    MGI:MGI:1915399
    See related
    Ensembl:ENSMUSG00000021203 AllianceGenome:MGI:1915399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OTB2; OTU2; 2010015L18Rik; 4930586I02Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and ubiquitin binding activity. Predicted to be involved in protein K11-linked deubiquitination; protein K48-linked deubiquitination; and protein K63-linked deubiquitination. Orthologous to human OTUB2 (OTU deubiquitinase, ubiquitin aldehyde binding 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 80.7), liver E14 (RPKM 6.9) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Otub2 in Genome Data Viewer
    Location:
    12 E; 12 52.92 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103343244..103372609)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103376894..103406350)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181, member A Neighboring gene predicted gene 29508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:104569739-104569961 Neighboring gene ankyrin repeat and SOCS box-containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E4038 Neighboring gene STARR-positive B cell enhancer ABC_E1863 Neighboring gene predicted gene 15523 Neighboring gene STARR-positive B cell enhancer ABC_E7174 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene predicted gene, 53758

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein K11-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K63-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin thioesterase OTUB2
    Names
    OTU domain-containing ubiquitin aldehyde-binding protein 2
    deubiquitinating enzyme OTUB2
    otubain-2
    ubiquitin-specific-processing protease OTUB2
    NP_001171312.1
    NP_080856.1
    XP_006516248.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177841.2NP_001171312.1  ubiquitin thioesterase OTUB2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC154347, AC160131
      Consensus CDS
      CCDS49150.1
      UniProtKB/TrEMBL
      D3Z0Y8
      Related
      ENSMUSP00000098655.3, ENSMUST00000101094.9
      Conserved Domains (1) summary
      pfam10275
      Location:90318
      Peptidase_C65; Peptidase C65 Otubain
    2. NM_026580.5NP_080856.1  ubiquitin thioesterase OTUB2 isoform 2

      See identical proteins and their annotated locations for NP_080856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC154347, AC160131
      Consensus CDS
      CCDS36528.1
      UniProtKB/Swiss-Prot
      Q3TUZ2, Q9CQX0, Q9D4K8
      Related
      ENSMUSP00000021620.7, ENSMUST00000021620.13
      Conserved Domains (1) summary
      pfam10275
      Location:1229
      Peptidase_C65; Peptidase C65 Otubain

    RNA

    1. NR_033587.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate promoter and lacks 5' coding exons compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of any downstream ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154347, AC160131

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103343244..103372609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516185.5XP_006516248.3  ubiquitin thioesterase OTUB2 isoform X1

      Conserved Domains (1) summary
      pfam10275
      Location:65292
      Peptidase_C65; Peptidase C65 Otubain