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    Ppp4r4 protein phosphatase 4, regulatory subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 74521, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp4r4provided by MGI
    Official Full Name
    protein phosphatase 4, regulatory subunit 4provided by MGI
    Primary source
    MGI:MGI:1921771
    See related
    Ensembl:ENSMUSG00000021209 AllianceGenome:MGI:1921771
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1622; 8430415E04Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase inhibitor activity. Acts upstream of or within blastocyst hatching. Predicted to be located in cytoplasm. Predicted to be part of protein serine/threonine phosphatase complex. Predicted to be active in cytosol. Is expressed in early conceptus; secondary oocyte; and telencephalon mantle layer. Orthologous to human PPP4R4 (protein phosphatase 4 regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 4.9), frontal lobe adult (RPKM 4.2) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Ppp4r4 in Genome Data Viewer
    Location:
    12 E; 12 52.95 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103498509..103580098)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103532250..103613839)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene interferon, alpha-inducible protein 27 like 2A Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within blastocyst hatching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein serine/threonine phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein serine/threonine phosphatase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein serine/threonine phosphatase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 4 regulatory subunit 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028980.3NP_083256.2  serine/threonine-protein phosphatase 4 regulatory subunit 4

      See identical proteins and their annotated locations for NP_083256.2

      Status: VALIDATED

      Source sequence(s)
      AK029499, BB307572, BC111887
      Consensus CDS
      CCDS36532.1
      UniProtKB/Swiss-Prot
      E9QKU6, Q14CI7, Q14DT1, Q69ZE5, Q8C0Y0, Q9CRR0
      Related
      ENSMUSP00000021631.6, ENSMUST00000021631.12
      Conserved Domains (2) summary
      PTZ00108
      Location:650875
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:214244
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103498509..103580098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244194.4XP_011242496.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X5

      See identical proteins and their annotated locations for XP_011242496.1

      UniProtKB/Swiss-Prot
      Q8C0Y0
      Related
      ENSMUSP00000139786.2, ENSMUST00000189871.7
      Conserved Domains (1) summary
      sd00044
      Location:214244
      HEAT; HEAT repeat [structural motif]
    2. XM_006516308.2XP_006516371.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1

      Conserved Domains (2) summary
      PTZ00108
      Location:655880
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:219249
      HEAT; HEAT repeat [structural motif]
    3. XM_006516314.4XP_006516377.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X3

      Conserved Domains (1) summary
      sd00044
      Location:219249
      HEAT; HEAT repeat [structural motif]
    4. XM_006516315.4XP_006516378.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X4

      Conserved Domains (1) summary
      sd00044
      Location:219249
      HEAT; HEAT repeat [structural motif]
    5. XM_030246960.1XP_030102820.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      Conserved Domains (2) summary
      PTZ00108
      Location:541766
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:105135
      HEAT; HEAT repeat [structural motif]
    6. XM_030246961.1XP_030102821.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      Conserved Domains (2) summary
      PTZ00108
      Location:541766
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:105135
      HEAT; HEAT repeat [structural motif]
    7. XM_030246962.1XP_030102822.1  serine/threonine-protein phosphatase 4 regulatory subunit 4 isoform X2

      Related
      ENSMUSP00000140874.2, ENSMUST00000187155.7
      Conserved Domains (2) summary
      PTZ00108
      Location:541766
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      sd00044
      Location:105135
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_003950088.1 RNA Sequence

    2. XR_001780496.2 RNA Sequence

    3. XR_381552.3 RNA Sequence