U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ifi27l2a interferon, alpha-inducible protein 27 like 2A [ Mus musculus (house mouse) ]

    Gene ID: 76933, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ifi27l2aprovided by MGI
    Official Full Name
    interferon, alpha-inducible protein 27 like 2Aprovided by MGI
    Primary source
    MGI:MGI:1924183
    See related
    Ensembl:ENSMUSG00000079017 AllianceGenome:MGI:1924183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ifi27; Isg12; Isg12(b1); 2310061N23Rik
    Summary
    Predicted to enable identical protein binding activity and molecular adaptor activity. Acts upstream of or within response to virus. Predicted to be located in nuclear envelope. Predicted to be active in mitochondrial membrane. Is expressed in embryo. Orthologous to several human genes including IFI27L2 (interferon alpha inducible protein 27 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 553.4), subcutaneous fat pad adult (RPKM 344.9) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ifi27l2a in Genome Data Viewer
    Location:
    12 E; 12 52.93 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103400132..103409939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103433873..103443680, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4039 Neighboring gene DEAD box helicase 24 Neighboring gene STARR-positive B cell enhancer ABC_E2393 Neighboring gene STARR-seq mESC enhancer starr_33125 Neighboring gene STARR-positive B cell enhancer ABC_E2394 Neighboring gene predicted gene, 53758 Neighboring gene interferon, alpha-inducible protein 27 Neighboring gene predicted gene, 53759 Neighboring gene interferon, alpha-inducible protein 27 like 2B Neighboring gene STARR-positive B cell enhancer ABC_E7175 Neighboring gene protein phosphatase 4, regulatory subunit 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in release of cytochrome c from mitochondria IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interferon alpha-inducible protein 27-like protein 2A
    Names
    interferon stimulated gene 12(b1)
    interferon-stimulated gene 12 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281830.1NP_001268759.1  interferon alpha-inducible protein 27-like protein 2A isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains an alternate 3' exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC154347, AK040279
      Conserved Domains (1) summary
      pfam06140
      Location:1267
      Ifi-6-16; Interferon-induced 6-16 family
    2. NM_029803.3NP_084079.1  interferon alpha-inducible protein 27-like protein 2A isoform 1 precursor

      See identical proteins and their annotated locations for NP_084079.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC154347, AK160503
      Consensus CDS
      CCDS49153.1
      UniProtKB/Swiss-Prot
      Q8R412
      Related
      ENSMUSP00000054698.9, ENSMUST00000055071.9
      Conserved Domains (1) summary
      pfam06140
      Location:1276
      Ifi-6-16; Interferon-induced 6-16 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103400132..103409939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157657.1XP_036013550.1  interferon alpha-inducible protein 27-like protein 2A isoform X1

      Conserved Domains (1) summary
      pfam06140
      Location:366
      Ifi-6-16; Interferon-induced 6-16 family